?

BIOGRAPHICAL SKETCH

?

NAME: Wen lan?Liu

?

POSITION TITLE: Professor

?

EDUCATION/TRAINING

?

A. Personal statement

I have trained as both an MD & PhD, and have gained more than 10 years of research experience in the USA. I have a broad research background in cardiovascular pharmacology, molecular biology, neuroscience, prenatal diagnosis and precision medicine. During my career I have co-authored more than 90 SCI research papers and received 24 research grants, including grants from the NIH, AHA and NSFC. At present, the focus of my research is primarily ischemic stroke, birth defects, and tumor precision medicine.

?

B. Positions and honors

Positions

2001-2002: Postdoctoral fellow, Reggio Emilia Hospital, Italy.

2002-2005: Postdoctoral fellow, School of Pharmacy, University of New Mexico, USA.

2005-2006: Research Scientist, School of Pharmacy, University of New Mexico, USA.

2006-2012: Assistant Professor, School of Pharmacy, University of New Mexico USA.

2006-2012: Associate?Professor, School of Pharmacy, University of New Mexico, USA.

2012-present: Professor, "B" category of overseas high-level talents in Shenzhen, Director of the Central Laboratory, Deputy Director of Prenatal Diagnosis Center, Deputy Director of Medical Genetics and Molecular Diagnosis Center, Shenzhen Second People's Hospital, Shenzhen, China.

?

Honors

2016: Award for Science and Technology, Beijing (2^nd position)

?

C. Representative publications (selected publications from the past five years)

1.Zhang X, Shen X, Dong J, Liu WC, Song M, Sun Y, Shu H, Towse CL, Liu W, Liu CF, Jin X.?Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats.?Cell Mol Neurobiol.?2019;?39(8):1151-1163.?(IF: 3.811)

2.Zhang XG, Song Y, Shan C, Wu XF, Tong YH, Jin XC, Liu W*, Zheng GQ* and Liu J*. Borneol Attenuates Ultrasound-Targeted Microbubble Destruction-Induced Blood–Brain Barrier Opening in Focal Cerebral Ischemia. Frontier Neurol. 2017; 8:704 (IF: 3.552)

3.Zhang Y, Yang K, Wang T, Li W, Jin X*, Liu W*. Nrdp1 increases ischemia induced primary rat cerebral cortical neurons and pheochromocytoma cells apoptosis via downregulation of HIF-1α protein. Frontier Cell Neurosci. 2017, 11:293.?(IF: 4.555)

4.Wang X, Xue GX, Liu WC, Shu H, Wang M, Sun Y, Liu CF, Liu W*.Liu J*, Jin X*.Melatonin alleviates lipopolysaccharide-compromised integrity of blood brain barrier through activating AMP-activated protein kinase in old mice. Aging Cell. 2017, 16(2): 414-421.?(IF: 6.714)

5.Rong P, Yu K, Weatherwax T, Zheng H, Liu W*, Liu KJ*. Blood occludin level as a potential biomarker for early blood brain barrier damage following?Ischemic Stroke. Sci Rep. 2017, 7:40331. (IF: 4.259)

6.Zhang Y, Wang T, Yang K, Xu J, Ren L, Li W*, Liu W*. Cerebral microvascular endothelial cell apoptosis after ischemia: role of enolase-phosphatase 1 activation and aci-reductone dioxygenase 1 translocation. Front. Mol. Neurosci. 2016, 9:79. ?(IF: 5.154)

7.Cai X^#,?Chen X^#, Wu S^#, Liu W^#?(^#Co-first author), Zhang X^#, Zhang D, He S, Zhang M, Zhang Y, Li Z, Luo K, Cai Z, Li W*. Homozygous mutation of VPS16 gene is responsible for an autosomal?recessive adolescent-onset primary dystonia. Sci. Rep. 2016, 6:25834.?(IF: 5.228)

8.Xu J, Zhang Y, Liang Z, Wang T, Li W, Ren L, Huang S*, Liu W*. Normobaric hyperoxia retards the evolution of ischemic brain tissue toward infarction in a rat model of transient focal cerebral ischemia.?Neurol. Res. 2016, ?38(1):75-9?( IF: 1.439)

9.Liu J, Weaver J, Jin X, Zhang Y, Xu J, Liu KJ, Li W*, Liu W*.Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells.?Mol Neurobiol. 2016, 53(9):?5935-5947?( IF: 6.190)

10.Jin X*, Sun?Y, Xu J, Liu W*.?Caveolin-1 mediates tissue plasminogen activator-induced MMP-9 upregulation in cultured brain microvascular endothelial cells. J. Neurochem.?2015, 132(6):724-30.? (IF:3.842).

?

D. Representative Research supports

1.?National Natural Science Foundation of China（grant no. 81873747）01/01/2019 to 12/31/2022，

PI Wenlan Liu，560,000 RMB

2.?National Natural Science Foundation of China（grant no. 81571149） ?01/01/2016 to 12/31/2019, ?

PI Wenlan Liu, 570000 RMB

3. Natural Science Foundation of Guangdong Province（grant no. 2016A030313027）06/01/2016 to 05/31/2019，

PI Wenlan Liu ，100,000 RMB

4.?Shenzhen Science and Technology Innovation Commission?(grant no. JCYJ20170413165705083）9/1/2017 to 8/31/2019，PI Wenlan Liu，3,000,000 RMB

5. Shenzhen Science and Technology Innovation Commission（grant no. JCYJ20170306093243010） 5/1/2017 to 4/30/2019，PI Wenlan Liu，250,000 RMB?

6.?Shenzhen Science and Technology Innovation Commission（grant no. JCYJ20170413104646428） 8/1/2017 to 7/31/2019，PI Wenlan Liu，2,000,000?RMB

7.?The Ministry of Education Research Funds (2015, 1098 Document）07/01/2015 to 06/30/2017,

PI Wenlan Liu，30,000?RMB

8. Shenzhen Science and Technology Innovation Commission（grant no. GCZX2015050411225563）07/01/2015 to 06/30/2018，PI Wenlan Liu, 3,000,000 RMB

?