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BIOGRAPHICAL SKETCH

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NAME: Xinyu Wang

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POSITION TITLE: Chief Physician

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EDUCATION/TRAINING

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A. Personal statement

Xinyu Wang is Professor, Chief Physician, Graduate Mentor, and Deputy Director of the Endocrinology and Metabolism Department of The First Affiliated Hospital of Shenzhen University. He is a member of the Thyroid Disease Branch of the Chinese Prevention Medicine Association, is Chairman of the Diabetes Professional Committee of the Shenzhen Physician Association, and is Vice?Chairman of both the Endocrinology Branch of the Shenzhen Medical Association?and of the MDT Branch of the Shenzhen Health Management Association.

He has been engaged in clinical and scientific research, and teaching of endocrinology and metabolic diseases for 33 years, and has served as a visiting professor at the Medical College of New York University and the Diabetes Research Center of Einstein Medical College. He has presided over more than 10 key scientific and technological projects in Guangdong Province, Henan Province and Shenzhen city, with a cumulative scientific research fund of more than 1 million yuan. He has published nearly 40 papers and 10 SCI papers, and has won two second-class awards for scientific and technological progress at both provincial and ministerial levels.

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B. Positions and honors

Positions

2004-2020Professor, The First Affiliated Hospital of Shenzhen University, Shenzhen,?China

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Honors

1.Second prize for "Drift and Significance of Th1/Th2 Related Cytokines in Autoimmune Thyroid Diseases" in Henan Province Scientific and Technological Progress (2000; certificate no. 00093) and Henan Province Medical and Health Scientific and Technological Achievements (2000; certificate no. 200026).

2.Third prize for "Pharmacokinetic study of cefotaxime in diabetic rats" in Scientific and Technological Progress in Henan Province (1997)

3.Awarded title "Shandong Provincial Excellent Postgraduate Cadre" (1999).

4.Awarded title?"Shandong Provincial Excellent Postgraduate" (1998).

5.Awarded title "Top Ten Outstanding Students of Shandong Medical University" (1997)

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C.?Representative publications (selected publications in last 5 years; 5–10)

1.Xin-Yu Wang, Lei Liu, Jie Cui, Cheng-Jie Song,?Jin-Song Bian,? Anna Sparatore, Piero Del Soldato, Chang-Dong Yan. H(2)S-Releasing Aspirin Protects against Aspirin-Induced Gastric Injury via Reducing Oxidative Stress. Plos One. 2012,7(9):e46301. (IF 4.96分)

2.Xu ZS, Wang XY, Xiao DM, Hu LF, Lu M, Wu ZY, Bian JS. Hydrogen sulfide protects MC3T3-E1 osteoblastic cells against H2O2-induced oxidative damage-implications for the treatment of osteoporosis. Free Radical Biology & Medicine. 2011,50(10):1314-1323. (IF 6.08分)

3.Wang XY, Peng YW, Ma YL, Jahroudi Nl. A Histone H1-like protein participates in endothelial cell specific activation of von Willebrand factor promoter. Blood. 2004, 104(104):1725-1732. (IF 10.12分)

4.Ma YL, Wang XY, Jiang W, Neubert TA. Identification of in vivo phosphorylation sites of human MCM2 by data-dependent NanoLC/ESI-MS/MS. A poster presented at the 50^th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, June 2-6, 2002.

5.Chen Shujuan, Lv Lingbo, Luo Guochun, Xue Yaoming, Wang Xinyu. Regulation of PGC-1α on Mitochondrial Biosynthesis in Vascular Endothelial Cells under High Glucose Condition. Shandong Medicine. 2009,49(29):20-21.

6.Wang Xinyu, Wang Guilan, Tian Zhigang. Th1/Th2 Subsets and Autoimmune Thyroid Diseases. Chinese Journal of Endocrinology and Metabolism. 2001,17(2):124-126.

7.Wang Xinyu, Li Quanzhong, Wen Shilin, Wang Guilan, Tian Zhigang. Characteristics of Th1/Th2-related cytokine profiles in Graves ophthalmopathy. Chinese Journal of Endocrinology and Metabolism. 2000,16(3):150-152.

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D. Research support

Ongoing projects (RMB)

1.The Role of Hydrogen Sulfide and Advanced Glycation End Product Receptors in Diabetic Atherosclerosis Project?No. 2018-2020 of Shenzhen Scientific and Technological Innovation Committee (No. GJHZ20180416164814621), Xinyu Wang, 100,000,000

2.Study on the Correlation between Hydrogen Sulfide and Graves’ Disease, No. 2015-2017 of Shenzhen Science and Technology Bureau (No. JCY2015033010272014), Xinyu Wang

3.Prohibition of production: evidence for hydrate sulfide as a?novel and powerful anti-hypertensive?drug (overseas cooperation). Fund source: National Medical Research fund Arch Council (NMRC)?2010-2013 Topic Number: R-184-000-167-216 (IDC: R-184-000-167-216 PI IRC R-184-000-701-733)

4.Study on the Relationship between Mitochondrial Biosynthesis and Oxidative Stress Induced by High Glucose in Cells; Key Research Project of Guangdong Provincial Science and Technology Department 2009-2011 (No. 2008B030301286), Xinyu Wang

5.Impact of Changes in Mitochondrial Biosynthesis on ROS Generation Induced by High Sugar. Science and Technology Research Project of Shenzhen Municipal Science and Technology Bureau 2007-2009 (No. 20062034), Xinyu Wang

6.Research on Specific Transcription Regulation of VWF Factor in Vascular Endothelial Cells Supported by National Institutes of Health (NIH) Project (HL-67729) 2003-2005, Xinyu Wang, US$ 100,000

7.Drift and Significance of Th1/Th2 related Cytokines in Autoimmune Thyroid Disease. Henan Provincial Science and Technology Committee?1998-2001 (No. 981170560), Xinyu Wang

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