BIOGRAPHICAL SKETCH

NAME: Xiuli Zhang

POSITION TITLE: Professor, Chief Physician

EDUCATION/TRAINING

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A.Personal statement

Xiuli Zhang, MD, Ph.D. Nephrology from China Medical University is a postdoctoral researcher at the Center for Molecular Medicine, Karolinska Institute, Sweden and at the State Key Laboratory of Cell Biology, China Medical University. Currently, she works as a Chief Physician in the Nephrology Department of Shenzhen Second People's Hospital, is a postgraduate supervisor at both Shenzhen University and Guangdong Medical University, and is a member of the Nephrology Branch of the Shenzhen Medical Association. She is mainly engaged in research into the pathophysiology and clinical medicine of diabetes and diabetic nephropathy. This is supported by the Nature Science Foundation of China (NSFC) general program, China Postdoctoral Science Foundation general programs, Provincial Natural Science Foundation general programs and other scientific research funds, with a total fund of 630,000 CNY. As the first or corresponding author, she has published more than 46 scientific papers in international journals including Metabolism: Clinical and Experimental, and has contributed to a monograph in the Handbook of Famine, Startup, and Rural Innovation published by Springer Nature, UK.

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B.Positions and honors?

Positions

2018-2020 Professor, Shenzhen University Health Sciences Center, Shenzhen, China

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Honors

2018Award for the second prize of Liaoning Province Natural Science Academic Achievement, Shenyang (First position)?

2017Award for Liaoning Province Natural Science Academic Achievement, Shenyang (First position)

2016Award for Scientific and Technological Progress of Benxi, Benxi (First position)

2015Award for Scientific and Technological Progress of Benxi, Benxi (First position)

2014Award for the second prize of Liaoning Province Natural Science Academic Achievement, Shenyang (First position)?

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C.Representative publications (selected publications in the last 5 years; 5–10)

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1.Zhang X, Guan T, Yang B,?et al. Protective effect of Berberine on high glucose and hypoxia-induced apoptosis via the modulation of HIF-1α in renal tubular epithelial cells. Am J Transl Res. 2019;11(2):669-682.

2.Zhang X, Gu HF, Frystyk J,?et al. Analyses of IGFBP2 DNA methylation and mRNA expression in visceral and subcutaneous adipose tissues of obese subjects. Growth Hormone & IGF Researc. 2019; 45:31-36. ?

3.Zhang X, Guan T,?Yang?B, et al. A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles. Metabolism: Clinical and Experimental. 2018(88):40-50.

4.Zhang X, Lian X, Liang D,?et al. Protective Effect of ZnT7 on High Glucose-induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells. Kidney and Blood Pressure Research. Kidney and Blood Press Res. 2018;43:500-512.

5.Zhang X, Liang D, Fan J,?et al. Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI- 3K Signaling. Biol Trace Elem Res.?2016;173(2):372-83.?

6.Zhang X, Liang D, Lian X et al. Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism. Apoptosis.?2016;21(6):721-36.

7.Zhang X, He H, Liang D,?et al. Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice. Int J Mol Sci. 2016;17(8).pii: E1327.

8.Chu Q, Chi ZH*, Zhang X*,?et al. A potential role for zinc transporter-7 in testosteronesynthesis in mouse Leydig tumor cells. Int J Mol?Med. 2016;37:1619-1626. *Co-corresponding authorship

9.Zhang X, Liang D, Guo L et al. Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1. Mol Med Rep.?2015;12:1347-1355.

10.Zhang X, Liang D, Chi Z et al. Effect of zinc on high glucose-induced epithelial-tomesenchymal transition in renal tubular epithelial cells. Int J Mol Med. 2015; 35: 1747- 1754.

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D. Research grant

Ongoing projects

Natural Science Foundation of China (No. 81670670), 2017-2020, Xiuli Zhang, PI, 580,000 CNY