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BIOGRAPHICAL SKETCH

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NAME: Zhenlin Zhao

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POSITION TITLE: Professor of Surgery

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EDUCATION/TRAINING

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A. Personal statement

Zhenlin Zhao, Ph.D, is a postdoctoral Scientist at Oxford University, Professor of Surgery, Chief Physician, ?and Director of the Department of Stem Cell & Regenerative Medicine, The First Affiliated Hospital of Shenzhen University. He is Executive Chairman of the International Organization for Stem Cell & Regenerative Medicine, Chief Scientist of Shenzhen Ruipuxun Institute of Stem Cell & Regenerative Medicine Research, Co-director and standing committee member of the International Cryotherapy Society (ISC), and standing committee member of the Asian Cryotherapy (ASC). Dr Zhao is also academic leader of provincial colleges and universities, and is an editorial board member of the?Journal of Modern Immunology, Journal of Clinical Medicine, and Current Report on Clinical Trial Studies and Outcomes. He is a graduate supervisor at Shenzhen University and Shanxi Medical University.

Dr Zhao’s research directions are in tumor immunity, and?his clinical direction is in tumor biotherapy and stem cell regenerative medicine. Dr Zhao was a postdoctoral fellow between 2007 and 2011 in the NDS Surgery Department of Oxford University; at the same period,?Dr Zhao majored in pancreatic transplantation and islet cell transplantation at Churchill Hospital, Oxford University. In 2013, Dr Zhao established the first Clinical Department of Stem Cell Regenerative Medicine at?The First Affiliated Hospital of Shenzhen University as Director. In the last 5 years, Dr Zhao has led a clinical study program in stem cell therapy in autoimmune diseases, diabetes, ulcerative colitis, ischemic stroke,?ALS, cirrhosis, nonunion of fractures, MLD gene therapy, and CAR-T treatment of solid tumors.

In term of the R & D position, Dr Zhao has undertaken a national natural science foundation project, and has jointly undertaken major national science and technology special projects: RPE transplantation for degeneration ?of retina. Dr Zhao has undertaken three provincial natural science foundation projects, two provincial scientific and technological research projects, one provincial talent fund project, and provincial education–science and a university-level funded project. Dr Zhao has been awarded prizes in two provincial science and technology progress awards and one provincial youth science and technology award.

Dr Zhao has published more than 50 publications in journals, including?Microsurgery, the?Journal of Experiment Medicine (JEM), the Chinese Journal of Hepatobiliary Surgery, the Chinese Experimental Journal, and the?Chinese Journal of Cardiothoracic Surgery.

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B. Positions and honors

Positions

1998-2013Chief Physician and Professor of Surgery, Department of General Surgery, The Second Clinical Medical College of Shanxi Medical University, Taiyuan,?Shanxi,?China

2007-2009Postdoctoral scientist,?Oxford University,?UK

2013-presentChief Physician and Professor of surgery, The First Affiliated Hospital of Shenzhen University,?Shenzhen,?Guangdong,?China

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Honors
#x200e2003Appraisal of scientific and technological achievements,?Shanxi

2004Award for Science and Technology Progress,?Shanxi (second prize)
2005Appraisal of scientific and technological achievements,?Shanxi

2006Award for Science and Technology Progress,?Shanx (second prize)

2007Award for Youth Science and Technology Award,?Shanxi

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C. Representative publications

1.Mingzhen Li, Huajing Teng, Zhenlin Zhao, Mei Zhao. Transcriptome profifiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression. Psychiatry Res.?276(2019)79-86

2.Zhenlin Zhao,?Min Fan,?Chenchen Huang,?Chenye Zhao.?Research status and Prospect of HBV specific cytotoxic T lymphocytes in the treatment of chronic hepatitis B.?Clinical Medicine Practice. 2019,28(12):931-934.

3.Zhenlin Zhao,?Chenye Zhao,?Yanbing?Xie,?Bo?Yang,?Jirong Su.?Effects of donor-Ag specific T cell vaccination on inhibiting Flt3-L-induced acute liver allograft rejection.?Chin J Immunol. 2016;32(3):327-331

4.Heth R. Turnquist, Zhenlin Zhao, Brian R. Rosborough, et al.?IL-33 Expands Suppressive CD11b+ Gr-1int and Regulatory T Cells, including ST2L + Foxp3+ Cells, and Mediates Regulatory T Cell-Dependent Promotion of Cardiac Allograft Survival. J Immunol. 2011;187;4598-4610

5.Fan Qiang, Zhao Zhenlin,?Wu Yongjie, Yanh Bo.?The evaluation on the changed to immune function and clinical symptoms for CIK/D-CIK treatment gastrointestinal tumor.?Proceeding of Clinical Medicine. 2016,25(01):3-7

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D. Ongoing projects (RMB)

National Basic Research General Program of Shenzhen (No.?JCYJ20180305164655077), 2019-2022, Jinlong Li ,?Zhenlin Zhao PI,￥500000