BIOGRAPHICAL SKETCH

NAME: Wu Guangyao

POSITION TITLE: Professor and Chief Physician?

EDUCATION/TRAINING

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A.?Personal statement

Research field,

1.?Functional magnetic resonance imaging (fMRI/DKI, DTI, IVIM-DWI/in vivo and in vitro HRMAS 1HMRS/VBM-MRI)

2.?Hyperpolarizing gas ¹²⁹Xe lung imaging

3.?Tumor quantitative imaging and tumor angiogenesis (DCE-MRI, DCE-CT and DCE PET imaging (including Cluster analysis).

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B. Positions and honors

Positions

Dr. Wu Guangyao (PHD. and MD) is a Radiology Professor and Director of the Radiology Department, at Shenzhen University General Hospital.

Honors

?“?¹H MRS research on?ischemic cerebral infarction”; Science-technology progress second-award of Hubei province in 2003 (first author, No: 2003J-218-2-072-066-R01)

?“¹H MRS research on cerebral space-occupying lesions and cerebral injury disease”, science-technology progress second-award of Hubei province in 2008 (first author, No: 2008J-251-2-063-059-R01) and science-technology progress second-award of Wuhan city in 2008 (first author, No: 2008J-127-2-038-004-01)

?“¹H?MRS research on cerebral space-occupying lesions and cerebral injury disease”; Science-technology progress second-award of Hubei province in 2008 (first author, No: 2008J-251-2-063-059-R01) and Science-technology progress second-award of Wuhan city in 2008 (first author, No: 2008J-127-2-038-004-01)

?“Study on plasticity the blind cerebral structure and function based on voxel morphological analysis and task-related fMRI” ; Science-technology progress second-award of Hubei province in 2010 (first author, No: 2010J-230-2-081-078-R01) and Science-technology progress second-award of Wuhan city in 2010 (first author, No: 2010J-118-2-47-017-01)

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C. Representative publications (selected publications in recent five years ? 5-10篇)

1?Li J, Wu G*, Wen Z, Zhang J, Lei H, Gui X, Lin F. White Matter Development is Potentially Influenced in Adolescents with Vertically Transmitted HIV Infections: A Tract-Based Spatial Statistics Study. AJNR Am J Neuroradiol. 2015 Nov;36(11):2163-9. doi: 10.3174/ajnr.A4417. Epub 2015 Jul 30.?

2?Zhu L, Wu G*, Zhou X, Li J, Wen Z, Lin F. Altered spontaneous brain activity in patients with acute spinal cord injury revealed by resting-state functional MRI. PLoS One. 2015, 13;10(3):e0118816. doi: 10.1371/journal.pone.0118816. eCollection 2015.

3?Wu G*, Yang S, Zhu L, Lin F. Altered spontaneous brain activity in heavy smokers revealed by regional homogeneity.?Psychopharmacology (Berl). 2015 Jul;232(14):2481-9.

4 Lin F, Wu G*, Zhu L, Lei H. Altered brain functional networks in heavy smokers. Addict Biol. 2015 Jul;20(4):809-19.

5?Wen Z, Zhang J, Li J, Dai J, Lin F, Wu G*. Altered Activation in Cerebellum Contralateral to Unilateral Thalamotomy May Mediate Tremor Suppression in Parkinson's Disease: A Short-Term Regional Homogeneity fMRI Study. PLoS One. 2016 Jun 16;11(6):e0157562. doi: 10.1371/journal.pone.0157562. eCollection 2016.

6?Wang P, Thapa D, Wu G*, Sun Q, Cai H, Tuo F. A study on diffusion and kurtosis features of cervical cancer based on non-Gaussian diffusion weighted model. Magn Reson Imaging.?2018 Apr;47:60-66. doi: 10.1016/j.mri.2017.10.016. Epub 2017 Nov 2.

7 Li J, Gao L, Wen Z, Zhang J, Wang P, Tu N, Lei H, Lin F, Gui X, Wu G*. Structural Covariance of Gray Matter Volume in HIV Vertically Infected Adolescents. Sci Rep.?2018 Jan 19;8(1):1182. doi: 10.1038/s41598-018-19290-5. ?

8?Wang X, Tu N, Qin T, Xing F, Wang , Wu G*. Diffusion Kurtosis Imaging Combined With DWI at 3-T MRI for Detection and Assessment of Aggressiveness of Prostate Cancer. AJR Am J Roentgenol. 2018 Aug 7:W1-W8. doi: 10.2214/AJR.17.19249. ?IF3.161

9?Li Y, Guo W, Su X, Lu N, Wu G*, Ou-Yang L, Dang M, Tao J, Teng Z. Facile preparation of near-infrared fluorescence and magnetic resonance dual-modality imaging probes based on mesoporous organosilica nanoparticles. J Colloid Interface Sci. 2019 15;539:277-286.

10?Tu N, Zhong Y, Wang X, Xing F, Chen L, Wu G*. Treatment?Response?Prediction of Nasopharyngeal?Carcinoma?Based on Histogram?Analysis of Diffusional?Kurtosis?Imaging. AJNR Am J Neuroradiol. 2019, 40(2):326-333. ?

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D. Research support

1 “ Task-fMRI study on smoking”, key fund of the Health Department of Hubei Province in 2004 ( No: 301140319 )

2 “Glioma phospholipid metabolism in vivo?¹H MRS or in vitro high-resolution ¹H MRS”, Hubei Province Natural Fund in 2007 (No. 2007ABA228)

3 “Resting state and smoking-clue fMRI study on the heavy smoker”, National Natural Fund for Youth in China in 2008 (No.30700192)

4 ^“1H MRS biomarker study of neural progenitor cells”, Natural Fund of Hubei Province in 2009 (No. 2009CDA071)

5 “Brain plasticity MRI study on rat spinal cord post-injury”, Wuhan University Project in 2010 (No. 303275894)

6 “Quantitative research on HIV-1 related neurocognitive disorder biomarkers based on 3.0T magnetic resonance with multi-modality imaging”, National Natural Fund in China in 2012 (No. 81171315)

7 “Research and Development of hyperpolarized ¹²⁹Xe MRI System for Human Pulmonary Critical Diseases”, National Special Instrument Projects in China in 2012, (the project eader is Prof. Xinzhou in WIPM. I am responsible for task V: The structure and function imaging in MRI to the human lung) (No. 81227902) ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?