BIOGRAPHICAL SKETCH 　 　

EDUCATION/TRAINING 　 　

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INSTITUTION AND LOCATION	DEGREE	Completion Date	FIELD OF STUDY　　 ?
West China University of Medical Sciences, Sichuan, ?China	B. Med	06/1988	Stomatology
The Chinese University of Hong Kong, Hong Kong	M.Phil.	07/2002	Anatomy
The Chinese University of Hong Kong, Hong Kong	Ph.D.	08/2005	Anatomy

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A.?? Personal Statement 　 　

My research interests mainly fall in the application and mechanism of ribosome-inactivating proteins on neurons and tumor cells. My research team members also explore the mechanism of lipid metabolism and the genes involved in cleft palate. Research in my lab is currently supported by the National Natural Science Foundation in China (NSFC) with 2 regular grants and Shenzhen with 1 key and 3 regular grants. I have published more than 50 papers in the peer-reviewed professional journals. I am currently mentoring 2 assistant professors and 3 MPhil candidates. 　 　

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B.?? Positions 　 　

Positions and Employment 　 　

07/1988 – 04/1995?????? Doctor-in-charge/Resident, Department of Stomatology, Beijing Tiantan Hospital, The Capital Medical University, Beijing, China 　 　

09/1999 – 12/2009?????? Research Associate/Teaching Assistant, Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 　 　

12/2009 – present????? Professor; Chair, Department of Anatomy, Histology and Development Biology , School of Biomedical Sciences; Associate Dean, School of Stomatology, Shenzhen University Health Science Center, Shenzhen, China 　 　

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Other Experience and Honors 　 　

1.??? Teaching Paper Award, Shenzhen University Health Science Centre, Shenzhen, China: 2013-2017 　 　

2.??? Excellent Undergraduate Course Award, Shenzhen University, Shenzhen, China: 2016 　 　

3.??? Excellent Supervisor Award for Master Degree, Shenzhen University, Shenzhen, China: 2014 　 　

4.??? The Second Prize of Teaching Achievement Award, Shenzhen University, Shenzhen, China: 2012 　 　

5.??? The Postgraduate Student Grant Award for Overseas Academic Activities, The Chinese University of Hong Kong, Hong Kong: 2005 　 　

6.??? The Quintiles Travel Grant Award, The American College of Toxicology, Bethesda, MD, U.S.A.: 2004 　 　

7.??? The Postgraduate Student Grant Award for Overseas Academic Activities , The Chinese University of Hong Kong, Hong Kong: 2004 　 　

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C.?? Research Support 　 　

Ongoing Research Support 　 　

NSFC (China) (81773939)????????????? ?????? ????????????????? 01/01/2018 to 12/31/2021　　

Ou Sha, PI ??????????????????????????????????????????? ????????????? ?????? ￥ 600,000　　

The mechanism and application of trichosanthin, a Traditional Chinese Medicine, in promoting T lymphocyte immunotherapy of mouse hepatoma 　 　

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Shenzhen Science and Technology Innovation Commission grant (JCYJ20170818141120342)??????????????????????? ???????????????????????????????????????????????????????????????????????????????????? 03/01/2018 to 03/31/2020　　

Ou Sha, PI??????????????????????????????????????????????????????????? ??????????? ￥ 500,000　　

The mechanism and application of trichosanthin in promoting the anti-lingual cancer activity of granzyme B 　 　

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Shenzhen Science and Technology Innovation Commission grant (JSGG20150512162446307)　　

???????????????????????????????????????????????????????????????????????????????????? ?06/01/2015 to 06/31/2018　　

Ou Sha, PI??????????????????????????????????????????????????????????? ￥ 4,500,000　　

The key techniques in the treatment of 3-negative breast cancer by the combination method of immune agonists and anthracyclines 　 　

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NSFC (China) (31771567)???????????????????? ????????????????? 01/01/2018 to 12/31/2021　　

Ou Sha, CI ????????????????????????????????????????????????????????? ?????? ￥ 570,000　　

Study on the Mechanism of Transporter Protein Complex II (TRAPP) and Small G Protein Rab18 in the Regulation of Lipid Droplets in Mammalian Cells and the Pathogenesis of Hepatic Fibrosis 　 　

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The Oversea High Level Team Project of Shenzhen　　

Ou Sha, team member???????????????????????????????????????? 01/01/2015 to 12/31/2019　　

????????????????????????????????????????????????????????????????????????????? ￥ 15,000,000　　

The innovation team for cancer stem cell immunotherapy 　 　

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Completed Research Support 　 　

Shenzhen Science and Technology Innovation Commission grant (GJHS20120621153317134)　　

???????????????????????????????????????????????????????? ????? ??????????????????01/01/2013 to 06/30/2016　　

Ou Sha, PI?????????????????????????????????????????????????????????????????? ????? ￥ 130,000　　

The mechanism of neurotoxicity of the traditional Chinese medicine, trichosanthin, on sensory neurons and its clinical applications　　

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NSFC (China) (81171154)??????????????????????????? ????????????? 01/01/2012 to 12/31/2015　　

Ou Sha, PI ????????????????????????????????????????????????????????? ?????? ￥ 550,000　　

The mechanism of neurotoxicity of the traditional Chinese medicine, trichosanthin, on sensory neurons and its possible clinical applications 　 　

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Shenzhen Science and Technology Innovation Commission grant (JCYJ20120613113228732)　　

10/01/2012 to 03/31/2015　　

Ou Sha, CI?????????????????????????????????????????????????????????????????? ￥ 500,000　　

The anti-tumor effect and mechanism of the traditional Chinese medicine, trichosanthin, on lymphoma　　

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D.?? B ooks publications [in Chinese] 　 　

1.????? Editor: [Histology and Embryology]. Higher Education Press, 2018.　　

2.????? Editor: [Histology and Embryology Practical Guide]. Higher Education Press, 2018.　　

3.????? Editor: [The Atlas of Histology and Embryology]. Higher Education Press, 2018.　　

4.????? Editor: [The Workbook of Histology and Embryology]. Higher Education Press, 2018.　　

5.????? Editor: [Histology and Embryology]. Higher Education Press, 2017.　　

6.????? O Sha*, Y Hao ， Eric YP Cho and Li Zhou. Clinical applications and side effects of ketamine. In: DTW Yew (ed) CRC press, USA. 2015, pp13-36.　　

7.????? Ou Sha, Maria Wai, Joyce Lam, Xinmin Fan. Histology Workbook for Medical & Health Science Students. People’s Medical Publishing House, 2015.　　

8.????? Editor: [Clinical anatomy dissection guide].? People’s Medical Publishing House. 2015.　　

9.????? Editor: [Faciology]. Xinjiang People’s Press. 2015.　　

10.?? Deputy Editor-in-chief: [Histology and Embryology Practical Guide]. Huazhong Science and Technology Press, 2013.　　

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E.??? Peer-reviewed publications (*: corresponding author) 　 　

1.????? Zeng MQ, Niu JF, Luan P, Ying Y, Pang RP, Su QN, Zhu HZ, Huang JQ, Chi HJ, Zhang LH, Fan XM, Sha O*. The Change of Nociceptive Neurons in the Rat Trigeminal Ganglia at Different Postnatal Ages. CNS Neurosci Ther. 2017 Feb;23(2):190-193.　　

2.????? Chi H, Li C, Zhao FS, Zhang L, Ng TB, Jin G, Sha O*. Anti-tumor Activity of Toll-Like Receptor 7 Agonists. Front Pharmacol. 2017 May 31;8:304. doi: 10.3389/fphar.2017.00304. eCollection 2017.　　

3.????? Li C, Zeng M, Chi H, Shen J, Ng TB, Jin G, Lu D, Fan X, Xiong B, Xiao Z, Sha O*. Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface. Oncotarget. 2017 Apr 18;8(16):26460-26470.　　

4.????? Wong JH, Cho Wing Sze S, Ng TB, Chi Fai Cheung R, Tam C, Zhang KY, Dan X, Chan YS, Chi Shing Cho W, Cheuk Wing Ng C, Miu Yee Waye M, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Yuen Sheung Ngan H, Sha O, Li G, Tse R, Tse TF, Chan H. Apoptosis and anti-cancer drug discovery: the power of medicinal fungi and plants. Curr Med Chem. 2017 Jul 20. doi: 10.2174/0929867324666170720165005.　　

5.????? Liu X, Liang JP, Sha O, Wang SJ, Li HG, Cho EYP. Protection of retinal ganglion cells against optic nerve injury by induction of ischemic preconditioning. Int J Ophthalmol. 2017 Jun 18;10(6):854-861.　　

6.????? Xue F, Zhang L, Zhang L, Ying Z, Sha O, Ding Y. One-and-a-half syndrome with its spectrum disorders. Quant Imaging Med Surg. 2017 Dec;7(6):691-697.　　

7.????? Wang Y, Qi W, Zhang L, Ying Z, Sha O, Li C, L? L, Chen X, Li Z, Niu F, Xue F, Wang D, Ng TB, Zhang L. The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study. Quant Imaging Med Surg. 2017 Oct;7(5):532-536.　　

8.????? Wang Y, Fan Y, Zhang L, Wang YX, Qi W, Liang W, Wang C, T W Yew D, Ye C, Sha O*. Bilateral Common Carotid Artery Occlusion in Spontaneously Hypertensive Rats: A Feasible Animal Model for Ocular Ischemic Syndrome. Anat Rec (Hoboken). 2016 Jun;299(6):806-14.　　

9.????? Zhu Y, Sun Y, Cai Y, Sha O*, Jiang W. Trichosanthin reduces the viability of SU DHL 2 cells via the activation of the extrinsic and intrinsic apoptotic pathways. Mol Med Rep. 2016 Jan;13(1):403-11.　　

10.?? Wang Z, Li B, Zhou L, Yu S, Su Z, Song J, Sun Q, Sha O, Wang X, Jiang W, Willert K, Wei L, Carson DA, Lu D. Prodigiosin inhibits Wnt/β-catenin signaling and exerts anticancer activity in breast cancer cells. Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13150-13155.　　

11.?? Chen S, Yuan L, Li Q, Li J, Zhu X, Jiang Y, Sha O, Yang X, Xin JH, Wang J, Stadler FJ, Huang P. Durable Antibacterial and Nonfouling Cotton Textiles with Enhanced Comfort via Zwitterionic Sulfopropylbetaine Coating. Small. 2016 Jul;12(26):3516-21.　　

12.?? Hong F, Wang L, Wu SL, Tang HC, Sha O, Wai MSM, Yew DT. A Review of Three Commonly Used Herbs Which Enhance Memory and New Evidences Which Show Their Combination Could Improve Memory in Young Animals. Mini Rev Med Chem. 2017;17(16):1537-1547.　　

13.?? Ye X, Ng CC, Wong JH, Ng TB, Chan GH, Guan S, Sha O. Ribosome-inactivating Proteins from Root Tubers and Seeds of Trichosan-thes kirilowii and Other Trichosanthes Species. Protein Pept Lett. 2016;23(8):699-706.　　

14.?? Haihui Wu; Meiqi Zeng; Eric Cho; Wenqi Jiang*; Ou Sha*. The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2 (MrgX2). Progress in Histochemistry and Cytochemistry 2015 Jun 8. pii: S0079-6336(15)00014-5. doi: 10.1016/j.proghi.2015.06.001. [Epub ahead of print]　　

15.?? Meiqi Zeng, Manyin Zheng, Desheng Lu, Jun Wang, Wenqi Jiang*, Ou Sha*. Anti-tumor activities and apoptotic mechanism of ribosome-inactivation proteins. Chin J Cancer 2015 Jul 17;34:30. doi: 10.1186/s40880-015-0030-x.　　

16.?? Junfei Niu, Chunman Li+, Haihui Wu, Xianling Feng, Qingning Su, Shihe Li, Lihong Zhang, David Tai Wai Yew, Eric Yu Pang Cho*, Ou Sha*. Propidium iodide (PI) stains Nissl bodies and may serve as a quick marker for total neuronal cell count. Acta Histochemica 2015 Feb, 117: 182-187.　　

17.?? Yilin Liang, Jian Zhang+, Tianshun Xie, Eric Yu Pang Cho, Dongsheng Hu, Baohua Liu, Lizu Xiao*, Ou Sha*. Hospitalized pain patients have recently doubled: a retrospective case series study in Shenzhen Nanshan People’s Hospital of China. Int J Neurosci 2015 Aug 20:1-7.　　

18.?? Yacong Wang, Qinying Cao, Lihong Zhang, Su'e Zhang, Liang Shi, Ou Sha*. Acute cortical blindness caused by pre-eclampsia in the antepartum; posterior reversible encephalopathy syndrome (PRES). Afr Health Sci Jun 2, 2015, 15(2): 723-6.　　

19.?? Akkouh O, Ng TB, Cheung RC, Wong JH, Pan W, Ng CC, Sha O, Shaw PC, Chan WY. Biological activities of ribosome-inactivating proteins and their possible applications as antimicrobial, anticancer, and anti-pest agents and in neuroscience research. Appl Microbiol Biotechnol. 2015 Sep 22. [Epub ahead of print]　　

20.?? Wai-Kai Wong, Anny Wan-Suen Cheung, Sau-Wai Yu, Ou Sha & Eric Yu Pang Cho. Hepatocyte Growth Factor Promotes Long-Term Survival and Axonal Regeneration of Retinal Ganglion Cells after Optic Nerve Injury: Comparison with CNTF and BDNF. CNS Neurosci Ther. 2014 Jul 3. doi: 10.1111/cns.12304. [Epub ahead of print]　　

21.?? Cheung RC, Wong JH, Pan WL, Chan YS, Yin CM, Dan XL, Wang HX, Fang EF, Lam SK, Ngai PH, Xia LX, Liu F, Ye XY, Zhang GQ, Liu QH, Sha O, Lin P, Ki C, Bekhit AA, Bekhit AE, Wan DC, Ye XJ, Xia J, Ng TB. Antifungal and antiviral products of marine organisms. Appl Microbiol Biotechnol. 2014 Feb 23. [Epub ahead of print]　　

22.?? Ou Sha, Yueli Sun, Yingjie Zhu, Liang Wang, Linwei Tian, Yacong Wang, Lihong Zhang, Wenqi Jiang*. The effects and possible mechanisms of trichosanthin (TCS) on cancer cells. Ann Anat 2014 Aug; 196S1: 262　　

23.?? Manyin Zheng, Haihui Wu, Wenqi Jiang, Ou Sha*. Trichosanthin (TCS) Inhibits the Proliferation of Glioblastoma A172 Cells by Promotion of Apoptosis. Ann Anat 2014 Aug; 196S1: 266-267.　　

24.?? Yilin Liang, Lizu Xiao, Jian Zhang, Dongsheng Hu, Xiaoyuan Fu, Eric Cho, and Ou Sha*. A retrospective study in the Pain Patients in Shenzhen Nanshan People’s Hospital, Shenzhen, China. Ann Anat 2014 Aug; 196S1: 262-263.　　

25.?? Junfei Niu, Chunman Li, Eric Cho, Ou Sha*. Propidium iodide (PI) stains Nissl bodies and may serve as a quick marker for total neuronal cell count. The 11th China-Japan Joint Seminar on Histochemistry and cytochemistry 2014: 122.?　　

26.?? Ou Sha, Wenqi Jiang, Miao Xie, Xinmin Fan, Zhigang Liu*. Teaching histology and embryology in English in the medical school of Shenzhen. Ann Anat 2014 Aug; 196S1: 231　　

27.?? Taraneh Afnan-Holmes, Dongsheng Hu, Ou Sha*. Learning Medical Terminology through Bridging the Known and Unknown. Ann Anat 2014 Aug; 196S1: 224　　

28.?? Tianshun Xie, Taraneh Afnan-Holmes, Miao Xie, Zhigang Liu, Xinmin Fan, Wing-Hang Kwong, and Ou Sha*. Cooperation between Histology and English Teaching Staff in Shenzhen University, China. Ann Anat 2014 Aug; 196S1: 221　　

29.?? O Sha*, JF Niu, TB Ng, EYP Cho, XY Fu, WQ Jiang. Antitumor action of trichosanthin, a type I ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review. Cancer Chemother Pharmacol 2013 Jun; 71(6): 1387-93.　　

30.?? X Liu, O Sha, EY Cho. Remote Ischemic Postconditioning Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury. J Mol Neurosci. 2013 Nov; 51(3): 639-46.　　

31.?? Ou Sha*. The anti-tumor activities of a type I ribosome-inactivating protein, trichosanthin, and its toxic mechanism on lymphoma cells. The 3rd World Congress on Cancer Science and Therapy, 2013:158.　　

32.?? WM Tong, O Sha*, TB Ng, EYP Cho and WH Kwong. Different in vitro toxicity of ribosome-inactivating proteins (RIPs) on sensory neurons and glial cells. Neuroscience Letters 2012, 524(2):89-94.　　

33.?? O Sha*, EYP Cho, DTW Yew, TB Ng and WH Kwong. Two Structural Similar Type I Ribosome-inactivating Proteins Showed Different In Vivo and In Vitro Toxic Mechanisms. The 14th International Congress of Histochemistry and Cytochemistry 2012:97.　　

34.?? O Sha*, WZ Shen, J Zhang, XL Feng, T Zhao and WH Kwong. The neurotoxic effects of intraneurally injected different ribosome-inactivating proteins (RIPs) on dorsal root ganglion neurons. Joint Annual Scientific Meeting of HKSN and BSHK ， 2012:85.　　

35.?? L Gao, S Chen, O Sha, X Li, J Zhang and X Liu. Dragon’s blood and its components inhibit the activity of Acid-sensing ion channels in rat sensory neurons. Joint Annual Scientific Meeting of HKSN and BSHK ， 2012:86.　　

36.?? Y Bai, J Wang, JP Wu, JX Dai, O Sha, DTW Yew, L Yuan and QN Liang. Review of evidence suggesting that the fascia network could be the anatomical basis for acupoints and meridians in the human body. Evid Based Complement Alternat Med 2011;2011:260510. Epub 2011 Apr 26　　

37.?? C Yang, DF Li, ZQ Wen, HY Yang, MC Yu, H Tao, RM Qu, YK Du, Y Huang, O Sha, JX Dai and L Yuan. Transplanted adipose-derived stem cells delay D-galactose-induced aging in rats. Neu Reg Res. 2011, 6(34): 2673-80.　　

38.?? H Tao, MC Yu, HY Yang, RM Qu, C Yang, X Zhou, Y Bai, JP Wu, J Wang, O Sha and L Yuan. Correlations between fasciology and yin yang doctrine. J Acupunct Meridian Stud. 2011 ， 4(2):141-6.　　

39.?? O Sha*, DT Yew, EY Cho, TB Ng, L Yuan and WH Kwong. Mechanism of the specific neuronal toxicity of a type I ribosome-inactivating protein, trichosanthin. Neurotox Res 2010, 18 (2): 161-72.　　

40.?? O Sha*, DT Yew, TB Ng, L Yuan and WH Kwong. Different in vitro toxicities of structurally similar type I ribosome-inactivating proteins (RIPs). Toxicol In Vitro 2010, 24 (4): 1176-82.　　

41.?? Z Li, HY Zhang, LX Lv, DF Li, JX Dai, O Sha, WQ Li, Y Bai and L Yuan. Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of beta-cells in Goto-Kakizaki rats. World J Gastroenterol 2010, 16: 2244-51.　　

42.?? Y Bai, L Yuan, KS Soh, BC Lee, Y Huang, CL Wang, J Wang, JP Wu, JX Dai, J Palhalmi, O Sha and DT Yew. Possible applications for fascia anatomy and fasciology in traditional Chinese medicine. J Acupunct Meridian Stud 2010, 3:125-32.　　

43.?? WZ Shen, O Sha*, DT Yew and WH Kwong. Retrograde transport of a traditional Chinese medicine, alpha-trichosanthin, and its selective neural toxicity. Clin Toxicol (Phila) 2009, 47: 876-83.　　

44.?? O Sha*, WH Kwong, YP Cho, DT Yew and TB Ng. Different neuronal toxicity of single-chain ribosome-inactivating proteins on the rat retina. Toxicon 2008, 51: 45-53.　　

45.?? O Sha* and WH Kwong. Postnatal developmental changes of vitreous and lens volumes in Sprague-Dawley rats. Neuroembryology and Aging 2006-07, 4: 183-8.?　　

46.?? SM Wai, WY Li, WY Chan, O Sha, and DT Yew. The iridopupillary membrane (or papillary membrane) in human development. Neuroembryology 2002, 1: 44-6.　　

47.?? DT Yew, O Sha, WWY Li, TT Lam and DE Lorke. Proliferation and apoptosis in the epithelium of the developing human cornea and conjunctiva. Life Sci 2001 ， 68: 2987-3003.　　

48.?? O Sha*, WH Kwong, YP Cho and DT Yew. Neuronal toxicity of type I ribosome-inactivating proteins (RIPs) on the rat retina. British Neurscience Assoc Abstr 2005, 18: 393.　　

49.?? SM Wai, WY Li, WY Chan, O Sha, and DT Yew. The iridopupillary membrane (or papillary membrane) in human development. Neuroembryology 2002, 1: 44-6.　　

50.?? DT Yew, O Sha, WWY Li, TT Lam and DE Lorke. Proliferation and apoptosis in the epithelium of the developing human cornea and conjunctiva. Life Sci 2001 ， 68: 2987-3003.　

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??????? Contact

??????? Email: shaou@szu.edu.cn

??????? Office Tel:?0755-86671916