ZHENDAN HE???

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I am Professor and Dean of the School of Pharmaceutical Science, Shenzhen University.

I obtained my Ph.D. in Pharmaceutical Sciences from Kyoto University in Japan in 1994, and completed my postdoctoral training at the Institute of Chemistry, Kyoto University and Gifu Pharmaceutical University in 1996.? I worked on medicinal plant chemistry in the National Key Laboratory in Kunming Institute of Botany, Chinese Academy of Sciences from 1996 to 1998, and then work as the project director at the Chinese University of Hong Kong in 2001.? I joined the International Cooperative Biodiversity Groups (ICBG) in 2001, and studied the structure of natural products at the School of Pharmacy, University of Illinois at Chicago.? In 2003, I was appointed Senior Investigator at the Institute of Chinese Medicine Limited, Hong Kong Jockey Club, and an expert of the Chinese Medicine Council of Hong Kong. In 2009, I was appointed Professor of the School of Medicine, Shenzhen University, and Dean of the School of Pharmaceutical Science.

I have been working on the structure and molecular mechanisms of Chinese medicines and natural small molecules, and novel drug development.? Dr. He has published >120 papers (with >1000 citations) on natural medical chemistry, the body’s anti-infection enhancement of natural small molecule or traditional Chinese Medicine inducing endogenous anti-viral cytokines, the material basis of active components.? I have seven patents, and have published two books and various chapters.? I have supervised seven Masters students, two Ph.D students, and four postdoctoral scholars.

I am a Councilman of the Guangdong Pharmacological Society, and a Board Member of the Professional Standardization Technical Committee of Guangdong Province. I am also an Evaluation Expert of the Shenzhen Science and Technology project, Shenzhen STIC National High and Novel Technology Enterprise Evaluation , the National Development and Reform Commission of Science and Technology Expert Committee, and the Guangdong Expert Commissioner of Biological Medicine Industry Technology Innovation Alliance.? In 2012, I was awarded Outstanding Supervisor of Shenzhen University, and Shenzhen high level talent.

? OFFICE TELEPHONE NUMBER：0755-26656406

??Email:hezhendan@szu.edu.cn

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Parts ofRepresentative Publications

1.?????? ANTI-INFLUENZA VIRUS EFFECTS OF CRUDE PHENYLETHANOID GLYCOSIDES ISOLATED FROM LIGUSTRUM PURPURASCENS VIA INDUCING ENDOGENOUS INTERFERON-g. ?X. P. Hu, M. M. Shao, S. Song, X. L. Wu, L. Qi, K. Zheng, L. Fan, C. H, Liao, C. Y. Li, J. He, Y. J. Hu, H. Q. Wu, S. H. Li, J. Zhang, F. X. Zhang, Z. D. He*. Journal of Ethnopharmacology 2016, 179: 128-136

2.?????? GYPENOSIDE L, ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM, INDUCES CYTOPLASMIC VACUOLATION DEATH IN HEPATOCELLULAR CARCINOMA CELLS THROUGH REACTIVE-OXYGEN-SPECIES-MEDIATED UNFOLDED PROTEIN RESPONSE. Kai Zheng, Chenghui Liao, Yan Li, Xinmin Fan, Long Fan, Hong Xu, Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Jian Zhang, Yifei Wang, Zhendan He*.Journal of Agricultural and Food Chemistry 2016, 1702-1711

3.?????? CRUDE SAPONINS OF PANAX NOTOGINSENG HAVE NEUROPROTECTIVE EFFECTS TO INHIBIT PALMITATE-TRIGGERED ENDOPLASMIC RETICULUM STRESS-ASSOCIATED APOPTOSIS AND LOSS OF POSTSYNAPTIC PROTEINS IN STAUROSPORINE DIFFERENTIATED RGC-5 RETINAL GANGLION CELLS. Dandan Wang, Huazhang Zhu, Shiwei Li, Jiaming Yang, Yang Xiao, Qiangrong Kang, Chenyang Li, Yunshi Zhao, Yong Zeng, Yan Li, Jian Zhang, Zhendan He*, Ying Ying. Journal of Agricultural and Food Chemistry 2016, 1528-1539

4.?????? INHIBITION OF AUTOPHAGOSOME-LYSOSOME FUSION BY GINSENOSIDE Ro VIA ER-β-p47^phox-ROS PATHWAY SENSITIZES ESOPHAGEAL CANCER CELLS TO 5-FLUOROURACIL-INDUCED CELL DEATH THROUGH CHK1-MEDIATED DNA DAMAGER RESPONSE. Kai Zheng, Yan Li, Shaoxiang Wang, Xiao Wang, Chenghui Liao, Xinmin Fan, Long Fan, Xiaopeng Hu, ?Qiangrong Kang, Yong Zeng, Xuli Wu, Haiqiang Wu, Haitao Xiao, Jian Zhang, Yifei Wang, Zhendan He *. Autophagy2016, 12: 1593-1613

5.?????? GYPENOSIDE L INDUCES AUTOPHAGY-ASSOCIATED CELL DEATH IN HUMAN ESOPHAGEAL CANCER CELLS THROUGH ENDOPLASM RETICULUM STRESS-MEDIATED Ca²⁺ RELEASE. Chenghui Liao, Kai Zheng, Yan Li, Hong Xu, Qiangrong Kang, Long Fan, Xiaopeng Hu, Yong Zeng, Xiaoli Kong, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Xiaohua Xiao, Yifei Wang, Zhendan He*. ONCOTARGET JOURNAL 2016, 7(30): 47387-47402

6.?????? THE ANTIVIRAL EFFECTS OF ACTEOSIDE AND THE UNDERLYING IFN-g INDUCING ACTION Xun Song, Jiang He, Hong Xu, Xiaopeng Hu, Xuli Wu, Haiqiang Wu, Lizhong Liu, Chenghui Liao, Yong Zeng, Yan Li, Yue Hao, Chenshu Xu Jian Zhang, Hongjie Zhang, Zhen-Dan He *. ?FOOD AND FUNCTION 2016，7(7): 3017-3030

7.?????? BIOASSAY GUIDED ISOLATION AND STRUCTURAL MODIFICATION OF THE ANTI-TB RESORCINOLS FROM ARDISIA GIGANTIFOLIA, Y. F. Guan, X. Song, M. H. Qiu, S. H. Luo, B. J. Wang, N. Van Hung, N. M. Cuong, D. D. Soejarto, H. H. S. Fong, S. G. Franzblau, S. H. Li, Z. D. He*, H. J. Zhang. CHEMICAL BIOLOGY & DRUG DESIGN 2016, 88(2): 293-301

8.?????? INDOLE ALKALOIDS FROM THE LEAVES OF NAUCLEA OFFICINALIS. L. Fan, Chenghui Liao, Qiangrong Kang, Kai Zheng, Yingchun Jiang, Z. D. He*. Molecules 2016, 21, 1?9

9.?????? DESIGN AND FABRICATION OF HYDROGEL-BASED NANOPARTICULATE SYSTEMS FOR IN VIVO DRUG DELIVERY. Wingfu Lai, Zhendan He*. Journal of Controlled Release 2016, 243, 260?282

10.?? NOX2-MEDIATED TFEB ACTIVATION AND VACUOLIZATION REGULATE LYSOSOME-ASSOCIATED CELL DEATH INDUCED BY GYPENOSIDE L, A SAPONIN ISOLATED FROM GYNOSTEMMA PENTAPHYLLUM. Kai Zheng, Yingchun Jiang, Chenghui Liao, Xiaopeng Hu, Yan Li, Yong Zeng, Jian Zhang, Xuli Wu, Haiqiang Wu, Lizhong Liu, Yifei Wang, Zhendan He*. Journal Agricultural and Food Chemistry 2017, 65, 6625?6637?

Contact

Email: hezhendan@126.com

Office Tel: 0755-26656406