BIOGRAPHICAL SKETCH 　 　

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NAME: ? ??????Wu, Xue qing ??????? ?? 　 　

POSITION TITLE: ?Professor of Obestetrics and Gynecology; Director of the 　 　

division of Obestetrics and Gynecology, Shenzhen University General Hospital, 　 　

Shenzhen University. 　 　

Email: wuxueqing.37@hotmail.com 　 　

Phone: 0755-21839055 　 　

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EDUCATION/TRAINING ??? 　 　

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Institution and Location ????DEGREE ?Completion Date ????Field of Study 　 　

Zhejiang University ,China ???B. Med ????07/1994 ???????????Clinical Medicine 　 　

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Wenzhou Medical University,China M.Sc. ?07/2000 ??Gynecological endocrinology 　 　

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King ’ s College London, UK ?????PhD ???08/2010 ??Reproduction, Development 　 　

and Endocrinology 　 　

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A.? Personal Statement 　 　

?? I have been a clinician of obstetrics and gynecology for more 24 years since graduation from Zhejiang University. Sponsored by National Education Committee, I attained my PhD degree in King’s College London UK in 2010. My research interests are as follows: a. epigenetic programming of reproductive axis by early life events; b. new material and strategy to repair the injury of endometrium; c. the pathogenesis and prevention of malignant tumor of female reproductive system. Research in my lab has been supported by the National Natural Science Foundation in China (NSFC) with 2 regular grants and other Provincial Natural Science Foundation with 4 regular grants. I have published more than 60 papers in the peer-reviewed professional journals. I am currently mentoring 6 Chinese MSc candidates and 3 oversea MSc candidates. 　 　

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B.? Positions and Honors 　 　

? Positions and Employment 　 　

??? ??? 1994----2000 ? ?? ? Resident doctor ?and Assistant Lecturer 　 　

?????????????????????Department of Obstetrics ? ＆ ? Gynaecology, 　 　

?????????????????????T he first affiliated hospital of Wenzhou Medical University . 　 　

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??? ??? 2000---- 2010 ?? ? Consultant and Lecturer 　 　

?????????????????????Department of Obstetrics ? ＆ ? Gynaecology, 　 　

?????????????????????T he first affiliated hospital of Wenzhou Medical University . 　 　

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?????? 20 10 ---- 2012 ?? ? Consultant and Reader 　 　

?????????????????????Department of Obstetrics ? ＆ ? Gynaecology, 　 　

?????????????????????T he first affiliated hospital of Wenzhou Medical University . 　 　

???????2012----2017 ??Consultant and Professor, Vice director for 　 　

?????????????????????Department of Obstetrics ? ＆ ? Gynaecology, 　 　

?????????????????????T he first affiliated hospital of Wenzhou Medical University . 　 　

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???????2017-----present ?Consultant and Professor, Director for 　 　

?????????????????????Department of Obstetrics ? ＆ ? Gynaecology, 　 　

?????????????????????Shenzhen University General Hospital

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Other Experience and Honors 　 　

1.? Editorial board, The Journal of Reproductive Medicine:2012-present 　 　

2.? Editorial Board, The Journal of Wenzhou Medical University, 　 　

2015- Present 　 　

3.? NSFC review panal (Reproduction and perinatal medicine):2013-2018 　 　

4.? Associate director, Society of gynecological endocrinology 　 　

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C.? Contributions to Science ? (*:corresponding author) 　 　

??? A full list of my publications (in a total of 63) is enclosed at the end of this document. 　 　

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1.? Epigenetic programming of hypothalamic-pituitary-ovarian axis in females. 　 　

2.? Kisspeptin/signaling system regulates the reproductive function. 　 　

3.? Injury and repair of the endometrium 　 　

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D.? Research Support 　 　

Ongoing Research Support 　 　

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NSFC (China) project (818 73822） ?01/01/2019 to 31/12/2022 　 　

Xueqing Wu, PI ?????????????????570,000 (direct cost) 　 　

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The mechanism of kisspeptin induced MAPK signaling pathway in the regulation of ovary dysfunction in PCOS. 　 　

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Shenzhen Science and Technology Innovation Commission grant （JCY20170818100355168） ??????01/01/2018 to 31/12/2019 　 　

Xueqing Wu, PI ??????????????????450,000 (direct cost) 　 　

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Mechanism of exercise improve reproductive dysfunction by kisspeptin/GPR54 system in obese rats 　 　

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Natural Science grant of Zhejiang Province (LY17H040009) ?01/01/2017 to 31/12/2019 　 　

Xueqing Wu, PI ???????????????80,000 (direct cost) 　 　

The mechanism of modulation on follicular development and ovulation by the signal systme of ovarian kisspeptin/GRP54 in obesity. ? 　 　

The Public Welfare Technology Project of Zhejiang Province ( 2016C37132) ?????????????????01/01/2016 to 31/12/2018 　 　

Xueqin Wu, PI ?????????????????????????????60,000 (direct cost) 　 　

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The prophylaInvestigation of the prolyphatice effect and the mechanism of ?temperature-regulated estradiol-heparin-poloxamer ydrogel in Asherman syndrome. 　 　

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Completed Research Support 　 　

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Wenzhou Science and Technology grant. ?(Y20140188) ???01/01/2015 to 31/12/2017 　 　

Xueqing W u, PI ?????????????????????????????50,000 (direct cost) 　 　

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The relationship between the autonomic innervation and reproductive loss in women. 　 　

The “H elp workers and agriculture "activities and projects for less developed areas in Wenzhou. ????????????????????????????????????????01/01/2015 to 31/12/2017 ???????????????????????????????????????? 　 　

Xueqing W u, PI ?????????????????????????????? 15,000 (direct cost) 　 　

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The clinical study of sex hormonal replacement therapy in perimenopausal and ?postmenopausal women. 　 　

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Scientific Research Foundation for the Returned Overseas Chinese Scholars of Chinese Ministry of Education (No.2012-1707). ???????????????01/01/2013-31/12/2015 　 　

Xueqing Wu, PI ??????????????????????????????30,000 (direct cost) 　 　

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The long term effect on reproduction by endotoxin in female rats. 　 　

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National Nature Science grant. ( 81100392) ????????????01/01/2012-31/12/2014 　 　

Xueqing Wu, PI ??????????????????????????????230,000 (direct cost) 　 　

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The long term effects of obesity in early life on the reproductive function in the female rats. 　 　

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Specialized Research Fund for the Doctoral Program of Higher Education of Chinese Ministry of Education (No.2011332112000). ??????????01/01/ 2012-31/12/2014 　 　

Xueqing Wu, PI ?????????????????????????????? ? 40,000 (direct cost) 　 　

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The programming effects on ovarian function by immune challenge in early life in female rats. ? 　 　

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Natural Science grant of Zhejiang Province (Y2110606). ???01/01 2011-31/12/2013 　 　

Xueqing Wu, PI ??????? ????????????????????????? 80,000 ?(direct cost) 　 　

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The programming effects of obesity in early life on the hypothalamic-pituitary-gonadal axis in the female rat. 　 　

Wenzhou Science and Technology grant. ?(H20100071) ???01/07/ 2010-30/06/2013 　 　

Xueqing Wu, PI ???????????? ???????????? 80,000 (direct cost) 　 　

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The long term programming effects of early life immunological stress on the female ovarian function and sympathetic adrenergic function. ? 　 　

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E Peer-reviewed publications (*:corresponding author) 　 　

1.? Xin-Xin Xu, Si-Si Zhang, Hui-Long Lin, Qi Lin,?Lai-En Shen, Emmanuel Ansong, and Xue-Qing Wu* Metformin Promotes Regeneration of the Injured Endometrium Via Inhibition of Endoplasmic Reticulum Stress-Induced?Apoptosis. Reproductive sciences ( in press) 　 　

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2.Chen YY, Wang BQ, Lan XX, Zhou ZY, Wu XQ *. Increased protein arginine methyl transferase 7 expression is correlated with the occurrence and development of endometrial carcinoma. Int J Clin Exp Med, 2018;11(5):4883-4990. 　 　

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3.Xu XX, Zhou ZY, Wu XQ* . Clinical analysis of adnexal twist in pubertal girls. Chinese general medicine. 2018；21（17）：2116-2119. 　 　

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4.Lan XX, Zhou ZY, Xu XX, Wu XQ * . T he mechanism of LncRNA FENDRR in the pathogenesis of cervical cancer. Journal of Wenzhou Medical University. 2018; 48（4）：262-266、 　 　

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5.? Wu XQ * , Xu XX, Zhou ZY, Quinn MJ. Re: Pre-eclampsia is primarily a placental disorder. The arteriolar injury in pre-eclampsia. BJOG 2018；125（4）：511-512. 　 　

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6. Zhou ZY, Xu XX, Wu XQ * . Effects on ovarian function in rodents. (Review). The journal of reproductive medicine. 2017; 26(11):1154-1157. 　 　

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7 . Wu XQ , Xu XX, Zhou ZY, Quinn MJ. ? Re: Clinical follow up of women after hypertensive disease in pregnancy and moderately elevated blood pressure during pregnancy and odds of hypertension later in life : The POUCHmoms longitudinal study Potential mechanisms for pregnant and nonpregnant women. BJOG ,2018;125(3):386-387 . 　 　

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8 . Wang BQ, Chen YY, Lan XX, Zhou ZY, Xu XX, Wu XQ* . The effect of neonatal immune challenge on reproduction by altering intraovarian kisspeptin/GPR54 system in the rat. Reprod Toxicol 2017 ;74:40-47 . 　 　

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9. Zhang SS, Xia WT, Xu J, Xu HL, Lu CT, Zhao YZ, Wu XQ* . Theree-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17β-estradiol on endometrial regeneration for intrauterine adhesions in a rat model. Internationl Journal of Nanomedicine, 2017;12：5643-5657. 　 　

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10. Xu HL, Xu J, Zhang SS, Zhu QY, Jin BH, ZhuGe DL, Shen BX, Wu XQ , Xiao J, Zhao YZ. Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF faciliate the morphologic and functional recovery of the injured rat uterus. Drug Deliv 2017; 24(1):867-881. 　 　

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11. Xu HL, Xu J, Shen BX, Zhang SS, Jin BH, Zhu QY, ZhuGe DL, Wu XQ , XJ, Zhao YZ. Dual regualations of thermosensitive heparin-poloxamer hydrogel using ?-polylysine:bioadhesivity and controlled KGF release for enhancing wound healing of endometrial injury. ACS Appl Mater Interfaces. 2017 Aug 24. 　 　

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12. Cai YY, Xu XX, Wu XQ * . The study of effects of injury of pelvic nerve and IL-10 on the pathogenesis of adenomyosis. Zhejiang Medicine, 2017;39(20):1-5. 　 　

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13 . Lu Y, Li W, Chen C， Wu XQ * . Efficacy of levonorgestrel intrauterine system in the treatment of dysfunctional uterine bleeding. The Journal of Reproductive Medicine, 2017;26(7):655-660. 　 　

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14 . Che n ?YY, Wang BQ, Lan XX, Wu XQ* . Expression of transferrin receptor in cervical carcinoma and its clinical significance. Journal of Wenzhou Medical University, 2017；47（4）：254-257. 　 　

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15. Lin T, Pan QH, Wu XQ * . The study of the different two kinds of surgery of treatment of cesarean scar defect. The Journal of Mathematical Medicine, 2017;30(3):323-324. 　 　

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16 . Wu XQ , Cai YY, Xia WT, Quinn MJ. The aetiology of pre-eclampsia, 1945-1953. BJOG, 2016; Dec;123(13):2130. 　 　

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17. ? Wu XQ , Cai YY, Xia WT, Quinn MJ. All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy. Obstet Gynecol, 2016 Dec; 128(6):1445-1446. 　 　

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18. ?Xia WT, Cai YY, Yang SM, Wu XQ , Quinn MJ. Prevalence of endometriosis during abdominal or laparoscopic hysterectomy for chronic pelvic pain. Obstet Gynecol, 2016 Sep;128(3):658. 　 　

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19. Wu XQ , Xia WT, Cai YY, Quinn MJ. Medical evacuation of the uterus and subsequent preterm labor. Am J Obstet Gynecol 2016 July 26. S0002-9378(16):30520-8. 　 　

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20 . XUE-QING WU , XIAO-FENG LI, WEI-TING XIA, BI-LU YE, KEVIN O’BYRNE. The effects on small litter rearing on ovarian function at puberty and adulthood in the rat. Reproductive Biology, 2016（2）；16:130-137. ???. 　 　

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21. QIANG-YONG ZHOU, HAI-YAN CHEN, SI-MENG YANG, YUE-HUA LI and XUE-QING WU* . Villoglandular papillary adenocarcinoma of the uterine cervix: A report of 4 cases and a review of the literature. Oncology letters 2016; 11(1):837-841. 　 　

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22. WU XQ , CAI YY, XIA WT, ZHANG SS, WANG BQ, Quinn MJ. Injuries to uterotubal nerves in advanced painless adenomyosis. International Society for Reproductive Surgery & the Fallopian tube, RCOG, Sep12-13, 2016. (Poster) 　 　

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23. WU XQ , CAI YY, XIA WT, ZHANG SS, WANG BQ, Quinn MJ. Neurologic injuries to the Fallopian tube in advanced painless adenomyosis. RCOG, Sep12-13, 2016.(Poster) 　 　

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24 .Wan L, Cai YY, Chen HY, Emmaneul Ansong, Wu XQ* . The relationship between injured uterosacral ligaments and ectopic pregnancy. Journal of Wenzhou Medical University，2016；46（9）：656-659. 　 　

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25 .Cai YY，Zhou QY, Emmanuel Ansong, Wu XQ* . The progress research on ?pelvic nerve abnormalities in adenomyosis. Journal of Wenzhou Medical University，2016, 46(4)：306-09. 　 　

22 .Chen C, Lu , Lu Y, Peng JW, Hu YJ, Lin XH, Wu XQ . Epidemiologic investigation on pelvic oor dysfunction among women in Wenzhou. Journal of Wenzhou Medical University，2016；46（3）：194-198. 　 　

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26.Chen C, Chen LX, Wu XQ*. ?Clinical studies of pregnant outcome of early-onset intrahepatic cholestasis of pregnancy. Journal of Wenzhou Medical University, 2015；45（8）：597-600. 　 　

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27.Xia WT, Yang SM, Wu XQ* .A nalysis of the hysteroscipic investigation in 341 cases of recurrent miscarriage. Journal of Wenzhou Medical Univers ity, 2015.4.25，45（04）：298-300. 　 　

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28 . Qiangyong Zhou, Haiyan Chen, Simeng Yang, Yuehua Li, Binqiao Wang, Yuanyuan Chen and Xueqing Wu* . High-fat diet decreases the expression of Kiss1 mRNA and kisspeptin in the ovary, and increases ovulatory dysfunction in postpubertal female rats. Reproductive biology and endocrinology 2014;12(1);127-138. 　 　

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29. X.Q. Wu , H.Y. Chen, L Wan and M. Quinn. Abnormal innervation of narrowed, uterine arterioles in cornual ectopic pregnancy. J Obstet Gynaecol, 2014(9):652-653. 　 　

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30. Ruefen Yu, Zhenzhen Zhu, Haibin Chen Huiyan Zhao, Xueqing Wu * . Invistigation of the relationship between vaginal irregular bleeding caused by Jini and the serum leptin level. Jornal of modern medicine , 2014.01.01，26（05）：607 - 608 　 　

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31. Wu XQ , Yang SM, Li YH, Zhou QY, Chen HY, Li HY. Long-term programing effects of obesity on the sympathoadrenal system in female rats. Journal of Wenzhou Medical University, 2014；44（3）：157-160. 　 　

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32. Baoyou Huang, Xueqing Wu , Qing Zhou, Yan Hu, Hongqin Zhao, Feiyun Zheng. Hua Zhu, Qian Zhang. Cushing’s Syndrome secondary to ectopic ACTH secretion from carcinoid tumor within an ovarian mature terotoma: a case report and review of the literatures. Gynecological Endocrinology, 2014;30(3):192-196. 　 　

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33 . Wu XQ , Zhou QY, Chen HY, Li XF, Li HY. Effect on the secretion of reproductive hormones in adult female rats exposed to lipopolysaccharide in neonatal life. National Medical Journal of China,2013;93(21):1674-1676. 　 　

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3 4.Gao MY, Du YM, Wu XQ , Zheng FY. Diagnosis and treatment of 17cases of ovarian Brenner tumor. Practical Oncology Journal,2013;(02):174-177. 　 　

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35 . Wu XQ , Li XF, Jin WW, Li HY. Effects of obesity on the lipid and glucose metabolism in female rats, National Medical Journal of China,2012;92(13):932-934. 　 　

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36 . Wu XQ , Li XF, Ye BL, Popat N, Milligan SR, Lightman SL, O’Byrne KT. Neonatal programming by immunological challenge: effects on ovarian function in the adult rat. Reproduction, 2011;141:241-248. 　 　

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37 . Wu XQ , Li XF, Ye BL. Influence on pubertal reproductive function in female rats by immune challenge in early life. Chinese Journal of Obstetrics and Gynecology,2011;46(6):441-445. 　 　

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38.Wu XQ , Chen XL, Bao Y, Zheng FY. Expression and clinical significance of matrix metalloproteinases，tissue inhibitors of metalloproteinases and CD44v6 in the endometrial carclno-a. Journal of Wenzhou Medical College，2011；41（1）：48-52. 　 　

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39 . Wu XQ , Zheng FY. The ?experience and exploration ?of teaching Obstetrics and Gynecology for international students. SCIENCE & TECHNOLOGYINFORMATION, 2011;252(03):186. 　 　

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40 . Knox AM, Li XF, Kinsey-Jones, Wilkinson ES, Wu XQ , Cheng YS, Milligan SR, Lightman SL, O’Byrne KT. Neonatal lipopolysaccharide exposure delays puberty and alters hypothalamic kiss1 and kiss1r mRNA expression in the female rat. J Neuroendocrinol, 2009; 21:683-689. 　 　

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41.Li XF, Kinsey-Jones JS, Knox AM, Wu XQ , Tahsinsory D, Brain SD, Lightman SL. O’Byrne KT. Neonatal lipopolysaccharide exposure exacerbates stress-induced suppression of luteinizing hormone pulse generator activity in the female rat. Endocrinology, 2007;148:5984-5990. 　 　

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42. Jiang CY, Pan AH, Wu XQ , Zhang XY, Wu WH. rterial embolization treatment of 4 cases of bleeding for the placenta previa in mid-term pregnancy. Journal of Practical Obstetrics and Gynecology,2007;23(06):381-382. 　 　

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43 .Pan AH，Jiang CY， Wu XQ , Zhang XY，Wu WH. Nursing care of middle trimester pregnancy patients with placental previa bleeding treated by arterial embolization. Nursing and Rehabilitation Journal,2007;6(3):209-210. 　 　

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4 4.Bao Y, Hu Y, Lin LL, Wu XQ . The relationship between intrahepatic cholestasis of pregnancy and perinatal infant outcome. Zhejiang Medical ???? 　 　

Journal,2006;28(11):924-925. 　 　

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45. Zhang WM, Shi ZZ, Wu XQ , Wu AZ. The urodynamic analysis of bladder dysfunction after hysterectomy. Chinese Journal of Obstetrics and Gynecology,2005;40(11):778-779. 　 　

46 . Wu XQ . Combinating immunity can effectively decrease intrauterine transmission and intrauterine infection of B type of hepatitis virus. Clinical medicine, 2005;25(6): 20-21. 　 　

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47 .Zhao HQ, Wu XQ , Bao XX, Zhou K, Chen YQ, Zeng XB. The Expression and Clinical Significance of Drug-resistance Genes GST-Л and LRP in Ovarian Carcinoma Tissue. Journal of Practical Obstetries and Gynecology,2005;21(3):171-173. 　 　

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48 .Zhan Lifei, Lin Wenqin, Ye Bilu, Wu Xueqing . Analysios of 10 cases of ectopic pregnancy companied with intrauterine pregnancy after sterilization in vivo and embryo transfer. Journal of Chinese emergency ,2004(13)5:344. 　 　

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49 .Ye Z, Wu XQ , Ni LS, Ye BL. The effect of nylestriol supplement on glycolipid metabolism of type 2 diabetes mellitus in postmenopausal Women. Chin J Diabetes,2004, (05):359-362. 　 　

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50 . Wu Xueqing , Li Haiying, Ye Bilu. Observation of Nylestriol replacement in postmenopausal female patients with coronary heart disease. Journal of practical obstetrics and gynecology. 2003, 2 (19):113-114. 　 　

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51.Zhang Wenmiao, Wu Xueqing . Study of the effect of combination of A-interferon and coagulation of cervical lesions in patients with cervical intraepithelial neoplasm. Journal of practical obstetrics and gynecology,2003(19)5:308—309. 　 　

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52. Wu Xueqing , Ye Bilu, Ye Zhen. Relationship of sex hormens and insulin resistaned in female Diabetes Mellitus patients. Guangxi Medical Journal, 2002(24)6:P857-860. 　 　

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53 .Chen Fengdi, Zheng Caiwei, Wu Xueqing. ?Evaluation of CA125 in patients with ovarian cancers. Wenzhou Medical College’s Journal, 2002(32)2:305—307. 　 　

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54 .Zhao Hongqin, Wu Xueqing . Analysis of 36 cases of borderline epithelial tumors of ovarian. Progress in Obstetrics and Gynecology, 2002(11):307-308. 　 　

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55 . Wu XQ , Li HY, Ye BL, Ye Z, Sun YX. The improvement to insulin resistance in type 2 diabetes mellitus in postmenopausal women by nylestriol. Chinese Journal of Gerontology,2002;22(1):20-22. 　 　

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56 . Wu Xueqing , Ye Bilu, Li Haiying, Ye Zhen. Estrogen replacement treatment improve insulin resistance in postmenopausal female patients with type 2 Diabetes Mellitus. Chinese Gynecology and Obestetrics Journal,2001;36(8):498-499. 　 　

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57 .Li Haiying, Wu Xueqing . Estrogen replacement improve lipid metabolism and insulin resistance in postmenopausal female coronary heart disease’s patients. Heart Journal,2001.8. 　 　

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5 8. Wu Xueqing , Ye Bilu, Ye Zhen. The effect of Nylestriol on postmenopausal women with type 2 Diabetes-Mellitus. Journal of Reproductive Medicine, 2001(10)5:296-299. 　 　

59 .Wang JX, Chen HJ, Wu XQ , Zhu QJ. An assessment of podophyllotoxin combined opin in treating condyloma acuminatum. Journal of Chinese Physician,2001;(7):548-548. 　 　

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60.Chen HJ, Wu XQ , Zheng FY, Wu AX, Jiang SF, Hu XX, Wang MS. Measurement of platelet αgrana membrane protein and fibrin in patients with pregnancy induced hypertension syndrome. Journal of Dalian Medical University,2001;(2):112-114. 　 　

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61. Wu Xueqing , Ye Bilu，Li Haiying. The influence of estrogen replacement on glucose metabolism in postmenopausal women. Journal of Chinese Physician, 2000;2(8):498-499. 　 　

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62. Wu Xueqing , Ye Xiuxia. The influence of hysterectomy on glucose, lipid and ovarian function in sexual maturity. Current Advance in Obstetrics and Gynecology,1999(8)2:50-152. 　 　

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63 .Hong W, Hu Y, Zeng XB, Chen HJ, Wu XQ . Effect of Valium on accelerating delivery during the active phase of labor in pregnant women. Journal of Wenzhou Medical College,1998;2(8):133-134.