BIOGRAPHICAL SKETCH　 　

NAME: Ma, Xiaosong　

POSITION TITLE: Professor of Physiology; Director of Diabetes Institute, Shenzhen University School of Medicine　 　

EDUCATION/TRAINING　 　

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A.?Personal?Statement　 　

There are two main threads to our current research. ①?the mechanism of insulin secretion from pancreatic β-cells， with?an?emphasis?on?the?role?of?epigenetically?regulation?of?ion?channels.?②?epigenetically?regulation?of differentiation?of?progenitor?β-cells.?We?study?mouse/rat?models?of?diabetes?as?well?as?normal?human?and?rodent β-cells. I have served as the founding director of the Diabetes Institute at Shenzhen University since 2010. Our research has been supported by the National Natural Science Foundation in China (NSFC) and the Strategic Funds for Scientific and Innovative Development of Shenzhen Municipality. I am currently mentoring 2 postdoctoral fellows and 3 post-graduated?students.　 　

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B.?Positions and Honors?Positions and?Employment　 　

07/1985–06/1988Assistant Professor,Department of Physiology, Hubei Medical University, China 07/1991 – 10/1996 Lecturer and Laboratory Director, Department of Physiology, Guangzhou?Medical　 　

University, China　 　

11/1996 – 11/1998 Associate Professor and Group Leader, Department of Physiology, Guangzhou Medical University, China　 　

11/1998?–?03/2000Visiting Scientist, Department of Neuroscience, Karolinska Institute, Sweden ?03/2009?–?presentProfessor,?Head?of?Diabetes?Institute,?Shenzhen?University?School?of?Medicine,?China　 　

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Memberships　 　

Member of the Society for Neuroscience (2007-2009)　 　

Member of the European Association of the Study of Diabetes (2001-2004) Member of American Diabetes Association (2002-2004)　 　

Member of Scandinavian Physiological Society (2003-2007) Member of the New York Academy of Sciences (2007- 2008)　 　

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Other Experience and Honors　 　

1.?NSFC review panel (Endocrinology & Diabetes):?2010-present　 　

2.?NSFC review panel (International Collaborative Program in Diabetes):?2015　 　

3.?Associate director, Diabetes Society of Chinese Research Hospital Association:?2016-present
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4.?Panel member, Chinese Association for Physiological Sciences:?2015-present　 　

5.?2006 Merit Award, University of?Oxford　 　

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C.?Research Articles (*: corresponding/co-corresponding ? author) 　 　

1.?? Jiang Z, Shi D, Tu Y, Tian J, Zhang W, Xing B, Wang J, Liu S, Lou J, Gustafsson Já, Hua X, Ma X*.(2018) ? Human Proislet Peptide Promotes Pancreatic Progenitor Cells to Ameliorate Diabetes Through FOXO1/Menin -Mediated Epigenetic Regulation. Diabetes. 67(7):1345-1355. 　 　

2.?? Jiang Z., Tian J., Zhang W, Yan H, Liu L, Huang Z, Lou J, Ma X *. (2017) Forkhead protein FoxO1 acts as a repressor to inhibit cell differentiation in human fetal pancreatic progenitor cells. J Diabetes Res. 2017:6726901. 　 　

3.? ? Muhammad AB, Xing B, Liu C, Naji A, Ma X, Simmons RA, Hua X. (2017) Menin and PRMT5 suppress ?GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. Am J Physiol Endocrinol Metab. 313 (2):E148-E166. 　 　

4.?? Feng Z, Wang L, Sun Y, Jiang Z, Domsic J, An C, Xing B, Tian J, Liu X, Metz DC, Yang X, Marmorstein R,Ma X*, Hua X（. ?2017） Menin and Daxx Interact to Suppress Neuroendocrine Tumors through Epigenetic Control ? of the Membrane Metallo-Endopeptidase. Cancer Res. 77(2):401-411 　 　

5.?? Ying Y, Zhu H, Liang Z, Ma X, Li S. （2015） GLP1 protects cardiomyocytes from palmitate-induced ?apoptosis via Akt/GSK3b/b-catenin pathway. J Mol Endocrinol. 55(3):245-62 　 　

6.?? Kong X., Zhang L., Hua X., Ma X*. (2015) Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway, J Diabetes Res. :803986. 　 　

7.?? Kong X, Yan D, Sun J, Wu X, Mulder H, Hua X, Ma X*. （2014 ）Glucagon-like peptide 1 stimulates insulin ?secretion via inhibiting RhoA/ROCK signaling and disassembling glucotoxicity-induced stress fibers. ?Endocrinology. 155(12):4676-4685. 　 　

8.?? Kong X, Yan D, Wu X, Guan Y, Ma X*. （2014 ）Glucotoxicity inhibits cAMP-protein kinase A-potentiated ?glucose-stimulated insulin secretion in pancreatic β-cells. J Diabetes.: 10.1111/1753-0407.12185 　 　

9.?? Zhang X, Liu J, Su W, Wu J, Wang C, Kong X, Gustafsson JA, Ding J, Ma X, Guan Y.（2013） Liver X ?receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an ?LXRα-SREBP1c- dependent mechanism. J Diabetes. 10.1111/1753-0407.12081. 　 　

10.?? Luo G, Kong X, Xu X, Wang H and Ma X*. （ 2013 ） Glucagon-like peptide 1 potentiates ?glucotoxicity-diminished insulin secretion via stimulation of cAMP-PKA signaling in INS-1E cells and mouse ?islets Int J Biochem Cell Biol.45(2):483-490. 　?

11.? Ying Y, Yan M, Cao W, Lu L, Kong X, Yan D, Zeng Q, Xu X, Qu J, Su Q and Ma X*.（2012）The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-Epac2-potentiated insulin secretion. FEBS letters,586(20):3674-3680. 　 　

12.? Ma X, Zubcebic L, Bruning JC, Ashcroft FM, Burdakov D. (2007) Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci. 27(7): 1529 -1533 . 　 　

13.? K?nner C,, Janoschek R, Plum L, Jordan S, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley M, Ashcroft F, Brüning JC (2007) Insulin Action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism 5(6):438-449 . 　 　

14.? MacDonald PE, Zhang De Marinis Y, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P (2007) A KATP Channel-Dependent Pathway within α-Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans. PLoS Biology 15;5(6):e143 　 　

15.? Salehi A, Eliasson L, Ma X, Rorsman P, Hakanson R, Lundquist I. (2007) Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: Evidence for the existence of insulinotropic agents in the stomach. Regul Pept. 139(1-3):31-8 . 　 　

16.? #Plum L, #Ma X, Hampel B, Balthasar N, Coppari R, Muenzberg H, Burdakov D, Gropp E, Janoschek R, Alber J,. Belgardt BF, Seibler J, Schwenk F, Suzuki A, Mak TW, Wittmann G, Fekete C, Krone W, Horvath TL, Ashcroft FM, Brüning JC (2006) Enhanced PIP3 signalling in POMC neurons causes obesity due to neuronal silencing via KATP channel activation. J Clin Invest. 116(7): 1886-1901 (# Joint first-author) . 　

17.? Vikman J, Ma X, Hockerman GH, Rorsman P, Eliasson L (2006) Antibody inhibition of SNAP-25 and syntaxin 1A clusters reduces rapid exocytosis in insulin-secreting cells. J Mol Endocrinol. 36(3):503-15 . 　 　

18.? Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L (2005) Glucagon stimulates exocytosis in mouse and rat pancreatic a-cells by binding to glucagon receptors. Mol Endocrinol.19(1):198-212 . 　?

19.? Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 432:226-30 . 　 　

20.? Gromada J, Ma X, H?y M, Bokvist K, Salehi A, Berggren PO, Rorsman P (2004) ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse a-cells. Diabetes.53 Suppl 3: S181-9 . 　

21.? Hansson K, Ma X, Eliasson L, Czerwiec E, Furie B,.Furie BC, Rorsman P, Stenflo J (2004) The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conusmarmoreus. J Biol Chem. 279(31):32453-63 . 　 　

22.? Kanno T, Ma X, Barg S, Eliasson L, Galvanovskis J, G?pel S, Larsson M, Renstr?m E, Rorsman P (2004) Large dense-core vesicle exocytosis in pancreatic b-cells monitored by capacitance measurements. Methods 33: 302-311 　 　

23.? G?pel S, Zhang Q, Eliasson L, Ma X, Galvanovskis J, Kanno T, Salehi A, Rorsman P (2004) Capacitance measurements of exocytosis in mouse pancreatic alpha-,beta- and delta cells within intact islets of Langerhans. J Physiol. 556(Pt 3):711-26 . 　 　

24.? #Eliasson L, #Ma X, #Renstr?m E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P (2003) SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic b-cells. J Gen Physiol. 121 (3); 181?197 (# Joint first-author) . 　 　

25.? Vikman J, Ma X, Tagaya M, Eliasson L (2003) Requirement for N-ethylmaleimide-sensitive factor for exocytosis of insulin-containing secretory granules in pancreatic b-cells. Biochem. Soc. Trans. 31, 842–847 . 　 　

26.? Olofsson CS, G?pel S, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P, Eliasson L(2002) Preferential release of docked granules during rapid insulin secretion in mouse pancreatic B-cells. Pflugers Arch 444: 43?51 . 　 　

27.? Barg S, Ma X, Eliasson L, Galvanovskis J, G?pel S, Oberm?llera S, Platzerc J, Renstr?m E, Trusb M, Atlasb D, Striessnigc J, Rorsman P (2001) Fast exocytosis with few Ca2+-channels in insulin-secreting mouse pancreatic b-cells. Biophys J 81 (6): 3308?3323 . 　 　

28.? Ma X, Tong YG, Schmidt R, Brown W, Payza K, Jodzic L, Pou C, Godbout C, H?kfelt T, Xu ZQ (2001) Effects of galanin receptor agonists on locus coeruleus neurons. Brain Res. 919(1): 169-174 . 　 　

29.? Xu ZQ, Ma X, Soomets U, Langel U, H?kfelt T (1999) Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on the hippocampal CA3 pyramidal neurons. Proc Natl Acad Sci USA, 96: 14583-14587 .

Contact

Email: xsma2008@yahoo.cn