BIOGRAPHICAL SKETCH 　 　

NAME: Gong, Peng ???????????????? Email: doctorgongpeng @szu.edu.cn ????????????????? Tel:+86- 0755- 21839068 　 　

POSITION TITLE: Professor and Director, Department of General Surgery, Shenzhen University School of Medicine 　 　

EDUCATION/TRAINING 　 　

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INSTITUTION AND LOCATION	DEGREE 　?	? Completion Date 　 　 MM/YYYY 　 　 　?	FIELD OF STUDY
Dalian Medical University, Dalian, China	B. Med	07/1994	Human Medicine
Dalian Medical University, Dalian, China	M.Sc.	07/1999	Human Medicine
Dalian Medical University, Dalian, China	MD. and PhD	08/2002	Human Medicine

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A.? Personal Statement 　 　

I am focus on molecular biology, clinical epidemiology, and evidence-based medicine of thyroid, breast and gastrointestinal cancers. I and my colleagues can perform minimally invasive surgery of hepatobiliary pancreatic diseases. Since 2014 years, I have been the director of Key Laboratory of Hepatobiliary and Pancreatic Disease Prevention and Treatment in Dalian and Key Laboratory of Molecular Targeted Drugs for Hepatobiliary and Pancreatic Tumors in Liaoning. My team has published several studies to clarify the mechanisms of liver and pancrease cancer. These projects were supported by National Natural Science Foundation in China (NSFC), Ministry of Education in China. In addition, we have published more than 150 papers in the peer-reviewed professional journals, such as Cancer Letter, Pancreas, International Journal of Surgery. I am currently mentoring 2 PhD candidates and 6 MSc candidates. 　 　 　?　 　 　

B.? Positions and Honors 　 　

Positions and Employment 　 　

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1994-08—1999-07 Resident of General Surgery, Dalian Medical University, China 　 　

1999-08—2003-08 Lecturer, Attending Physician of General Surgery, Dalian Medical University, China 　 　

2003-09—2006-08 Associate Professor of General Surgery, Dalian Medical University, China 　 　

2004-03—2004-09 Member of National Natural Science Foundation of China 　 　

2007-03—2007-06 Guesting researcher, Heidelberg University, Germany 　 　

2007-08-present Professor of General Surgery, Dalian Medical University, China 　 　

2018-03-present Director of General Surgery, General Hospital of Shenzhen University 　 　

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Organizing International Meetings 　 　

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Other Experience and Honors 　 　

　 　

1. Associate Editor, Liaoning Medical Journal 　 　

2. Chinese Medical Association Liaoning Branch Clinical Epidemiology and Evidence-Based Medicine Hou Ren Chairman 2016.9-2020.9 　 　

3. Vice Chairman of the Chinese Association of Preventive Medicine, Liaoning Province Chronic Disease Prevention and Treatment Oncology Branch 2016.8-2020.8 　 　

4. China Medical Education Association Abdominal Oncology Professional Committee 2016.8-2020.8 　 　

5. Member of the Chinese Physician Association Committee of Biliary Surgeons 2015.6-2018.6 　 　

6. Member of the ERAS Society of Chinese Research Hospital Association 　 　

7. Member of the biliary tract group of the Youth Research Society of the Chinese Medical Association Surgery Branch 　 　

8. Deputy Director of the Department of Liver Surgery, Department of Surgery, Liaoning Provincial Medical Association, Chinese Medical Association 2015.6-2018.6 　 　

9. Standing Committee Member of the Chinese Medical Association Liaoning Medical Association Trauma Branch 2014.12-2017.12 　 　

10. Member of the Chinese Society of Parenteral Enteral Nutrition of Liaoning Province 2015.11-2018.11 　 　

11. Member of the Medical Science Research Management Branch of the Liaoning Medical Association of the Chinese Medical Association 2014.1-2018.1 　 　

12. Member of the Chinese Medical Association Liaoning Provincial Branch Clinical Epidemiology and Evidence-Based Medicine 2012.9-2016.9 　 　

13. Chinese Medical Association Liaoning Provincial Surgery Branch Member of the Critical Care Group 2009.9-2013.9 　 　

14. Liaoning Branch of Chinese Medical Association Dalian Branch Deputy Director of Clinical Epidemiology and Evidence-Based Medicine 2012.9-2016.9 　 　

15. China Research Hospital Association Precision Medicine and MDT Tumor Clinical Collaboration Group Standing Committee 2017.01-2019 　 　

16. Deputy Director of the 2nd Special Committee on Biliary Tumors of Liaoning Anti-Cancer Association 2017.02-2021 　 　

17. Liaoning Provincial Society of Immunology General Surgery Immunization Branch Deputy Director 2017.08-2021 　 　

18. Liaoning Provincial Physician Association Surgeons Branch Section 1 Members 2017.07-2020 　 　

19. Member of the General Branch of General Surgery of Dalian Medical Association 2013.11-2016.11 　 　

20. Member of the Scientific Research Management Branch of Dalian Medical Association 2013.11-2016.11 　 　

21. Member of the Medical Ethics Branch of Dalian Medical Association 2013.11-2016.11 　 　

22. Executive Deputy Director of the Cancer Nutrition Committee of the China Anti-Aging Promotion Association 2017.10-2022 　 　

23. The First Surgeon Branch of Guangdong Medical Doctor Association 2018-2022 　 　

24. International Hepatobiliary and Pancreatic Association China Branch Biliary Stone Committee 2018-2023 　 　

25. International Hepatobiliary and Pancreatic Association China Branch Biliary Cancer Committee 2018-2023 　 　

26. Member of the Hepatobiliary and Pancreatic Surgery Committee of the Cross-Strait Medical and Health Exchange Association 2018-2023 　 　

27. Standing Committee of Gastrointestinal Oncology Committee of Shenzhen Medical Doctor Association 2018-2023 　 　

28. Member of the Cancer Nutrition Committee of China Anti-Cancer Association 2018-2022 　 　

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C.? Contributions to Science (*: corresponding/co-corresponding author) 　 　

1.? Pancreaticoduodenectomy 　 　? ?　

Pancreaticoduodenectomy (PD) is the standard operative procedure for a variety of malignant and benign diseases of the pancreas and periampullary region. With improvements in surgical technique and perioperative management, the mortality rate associated with this procedure has decreased to less than 5 %; however, the overall postoperative complication rate remains high, at 30–60 %. Postoperative pancreatic fistula (POPF), with a prevalence of 5–35 % after PD, is the most feared complication, leading to many other postoperative complications and deaths. Therefore, we performed several studies to evaluate different strategies to prevention and treatment of POPF. Our studies showed that pancreaticogastrostomy is superior to pancreaticojejunostomy. In addition, pancreaticoduodenectomy is safe for elderly patients. 　 　 　?　 　 　

1) Zhang X, Dong X, Liu P, Yan Y, Wei Y, Zechner D, Gong P * , Vollmar B.Binding versus Conventional Pancreaticojejunostomy in Preventing Postoperative Pancreatic Fistula: A Systematic Review and Meta-Analysis. Dig Surg,2017,34(4):265-280. 　 　? ? 　 　

2) Zhang X, Ma L, Gao X, Bao H, Liu P, Aziz A, Wang Z, Gong P* ? Pancreaticogastrostomy versus pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Surg Today，2014 Sep 26. [Epub ahead of print] 　 　? ?　 　 　

3) Lu L, Zhang X, Tang G, Shang Y, Liu P, Wei Y, Gong P * , Ma L. Pancreaticoduodenectomy is justified in a subset of elderly patients with pancreatic ductal adenocarcinoma: A population-based retrospective cohort study of 4,283 patients. Int J Surg,2018 May;53:262-268. doi: 10.1016/j.ijsu.2018.03.054. Epub 2018 Mar 2 　 　? ? 　 　

2.? Pancreatic neuroendocrine neoplasms 　 　

Neuroendocrine neoplasms (NENs) are epithelial tumors with a predominant neuroendocrine differentiation, and they can develop in most organs. This fairly rare neoplasms displays a large spectrum of clinical presentations. According to the Surveillance, Epidemiology and End results (SEER) database, more than half of all NENs are gastroenteropancreatic NENs (GEP-NENs) (61%), with the highest frequency being observed in the rectum (17.7% of NENs), small intestine (17.3% of NENs) and colon (10.1% of NENs), followed by the pancreas (7.0%), stomach (6.0%), and appendix (3.1%). The annual incidence of GEP-NENs is about 3.65-4.7 cases per 100,000 people in the United States (USA). African Americans show a higher incidence than Caucasians (6.46 vs. 4.60 per 100,000). The incidence is also slightly higher in men compared with women (4.97 vs. 4.49 per 100,000). Similar rates were reported in Sweden, Norway, Spain and England. Many studies reported the epidemiology, diagnosis, pathology and management of GEP-NENs in the American and the European populations, but there is a lack of data in Asian populations, especially in China.Therefore, the objective of the present study was to perform an epidemiological study of GEP-NENs in a Chinese population. The present study might provide new clues about the development and the management of these rare tumors. 　 　? ? 　 　

1) Zhang X, Ma L, Gao X, Bao H, Liu P, Aziz A, Wang Z, Gong P* ? Pancreaticogastrostomy versus pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: a meta-analysis of randomized controlled trials. Surg Today，2014 Sep 26. [Epub ahead of print] 　 　

2) Zhang X, Lu L, Liu P, Cao F, Wei Y, Ma L, Gong P * ? Predictive Effect of the Total Number of Examined Lymph Nodes on N Staging and Survival in Pancreatic Neuroendocrine Neoplasms.Pancreas,2018,47(2):183-189. doi: .10.1097/MPA.0000000000000987. 　 　

3) Peng Liu, Xianbin Zhang, Yuru Shang, Lili Lu, Fei Cao, Min Sun, Zhaohui Tang, Brigitte Vollmar, Peng Gong * ?Lymph node ratio, but not the total number of examined lymph nodes or lymph node metastasis, is a predictor of overall survival for pancreatic neuroendocrine neoplasms after surgical resection.Oncotarget,2017,47(4):1-4 ? 　 　

3.? Autophagy 　 　

Autophagy and Hippo-YAP1 signaling pathway, two processes, has been reported to regulate the pathophysiology of cancer and the sensitivity to chemotherapy. We tried to clarify mechanisms of autophagy and Hippo-YAP1 pathway. We observed that bafilomycin A1, an inhibitor of autophagy, induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. In addition, we found tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. 　 　 　 　

1) ?Yan Y, Jiang K, Liu P, Zhang X, Dong X, Gao J, Liu Q, Barr MP, Zhang Q, Hou X,Meng S, Gong P * . Bafilomycin A1 induces caspase-independent cell death inhepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. SciRep,2016,15(6):37052. ?doi: 10.1038/srep37052. 　 　

2) ?Ke Jiang, Min Liu, Guibin Lin, Beibei Mao, Wei Cheng, Han Liu, Jozsef Gal, Haining Zhu, Zengqiang Yuan, Wuguo Deng, Quentin Liu, Peng Gong * , Xiaolin Bi, Songshu Meng. Tumor suppressor Spred2 interaction with LC3 promotesautophagosome maturation and indu ces autophagy-dependentcell death.Oncotarget, 2016, 7(18):25652-25657. 　 　

3) ?Zhen Li,Ke Jiang,Xiaofang Zhu,Guibin Lin,Fei Song,Yongfu Zhao,Yongjun Piao,Jiwei Liu,Wei Cheng,Xiaolin Bi, Peng Gong * , Zhiqi Song,Songshu Meng.Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma ?cells. Cancer Lett, 2016,370(2):332-44. doi: 10.1016/j.canlet.2015.11.015. Epub 2015 Nov 14. 　 　? ? 　 　? ? 　 　

D.? Research Support 　 　 　 　

1. Liaoning Provincial Department of Human Resources and Social Security 2016 to 2018 　 　

Peng Gong, PI 20,000 　 　

Based on PPARs-NF-κB Signaling Pathway to Explore the Mechanism of Hepatic Biliary Injury and the Protective Effect of Shenqi Fuzheng 　 　

2. Excellent talent support program for higher education institutions in Liaoning Province 　 　

Number: LR201518 2015-2018 2015 to 2018 　 　

Peng Gong, PI 100,000 　 　

Use glycoproteomics technology to explore early diagnostic markers for serum proteins of pancreatic cancer 　 　

3. The National Natural Science Foundation of China 2015-2018 　 　

Number: 81473504 830,000 　 　

Peng Gong, PI 　 　

The effect of bone marrow mesenchymal stem cells on the protective effect of hepatocytes in the gallbladder cells. 　 　

4. ?Distinguished Professor of Liaoning Province 　 　

Peng Gong, PI 2013-2017 　 　

The role and mechanism of peroxisome proliferator-activated receptors in liver injury of biliary 　 　

obstruction 　 　

5. ?National Natural Science Foundation of China 2006-2008 　 　

Number: 30570110 300,000 　 　

Peng Gong, PI 　 　

???????????The role and mechanism of peroxisome proliferator-activated receptors in liver injury of biliary 　 　 ?　 　 　

E.? Peer-reviewed publications (*: corresponding author) 　 　

1.? Liu M,?Jiang K,?Lin G,?Liu P,?Yan Y,?Ye T,?Yao G,?Barr MP,?Liang D,?Wang Y,? Gong P ,?Meng S,?Piao H. Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation.J Exp Clin Cancer Res. 2018 Jul 24;37(1):165. doi: 10.1186/s13046-018-0806-3 .(深大、卡尔森) 　 　

2.? Lu L,?Zhang X,?Tang G,?Shang Y,? Liu P ,?Wei Y,?Gong P,?Ma L. Pancreaticoduodenectomy is justified in a subset of elderly patients with pancreatic ductal adenocarcinoma: A population-based retrospective cohort study of 4,283 patients. Int J Surg,2018 May;53:262-268. doi: 10.1016/j.ijsu.2018.03.054. Epub 2018 Mar 29 (IF:2.693) 单位:The First Affiliated Hospital of Dalian Medical University, China; Department of General Surgery, The Shenzhen University General Hospital and Shenzhen University School of Medicine, China. 　 　

3.? Zhang X,? Lu L ,?Liu P,?Cao F,?Wei Y,?Ma L,?Gong P. Predictive Effect of the Total Number of Examined Lymph Nodes on N Staging and Survival in Pancreatic Neuroendocrine Neoplasms. Pancreas,2018,47(2):183-189. doi: .10.1097/MPA.0000000000000987. ?(IF:2.958) 　 　

4.? Zhu L, Wang L, Cao F , Liu P, Bao H, Yan Y, et al. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1 ‐ mediated deacetylation of FXR and PGC ‐ 1α. Journal of Hepato-Biliary-Pancreatic Sciences,2018,25(3): ?195-205 (IF:2.877) ?Department of Hepatobiliary Surgery, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian 116011, China. 　 　

5.? Peng Liu, Xianbin Zhang, Yuru Shang, Lili Lu,Fei Cao,Min Sun, Zhaohui Tang,Brigitte Vollmar, Peng Gong .Lymph node ratio, but not the total number of examined lymph nodes or lymph node metastasis, is a predictor of overall survival for pancreatic neuroendocrine neoplasms after surgical resection.Oncotarget,2017,47(4):1-4 ?IF：5.1652 　 　

6.? Zhang X, Dong X, Liu P, Yan Y, Wei Y, Zechner D, Gong P, Vollmar B.Binding versus Conventional Pancreaticojejunostomy in Preventing Postoperative Pancreatic Fistula: A Systematic Review and Meta-Analysis. Dig Surg,2017,34(4):265-280.IF:1.66 　 　

7.? Zhang X, Lu L, Shang Y, Liu P, Wei Y, Ma L, Gong P.The number of positive lymph node is a better predictor of survival than the lymph node metastasis status for pancreatic neuroendocrine neoplasms: A retrospective cohort study.International Journal of Surgery.2017,2(48):142-148. IF:2.2 　 　

8.? Yan Y, Jiang K, Liu P, Zhang X, Dong X, Gao J, Liu Q, Barr MP, Zhang Q, Hou X,Meng S, Gong P. Bafilomycin A1 induces caspase-independent cell death inhepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. SciRep,2016,15(6):37052. ?doi: 10.1038/srep37052. PubMed PMID: 27845389; PubMedCentral PMCID: PMC5109251.IF 4.2 　 　

9.? Haidong Bao, Peng Liu, Ke Jiang, Xianbin Zhang, Long Xie, Zhongyu Wang and Peng Gong. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncology Letters, 2016, 12: 1058-1066 ??(1.48 ) 　 　

10.? Ke Jiang, Min Liu, Guibin Lin, Beibei Mao, Wei Cheng, Han Liu, Jozsef Gal, Haining Zhu, Zengqiang Yuan, Wuguo Deng, Quentin Liu, Peng Gong, Xiaolin Bi, Songshu Meng. Tumor suppressor Spred2 interaction with LC3 promotesautophagosome maturation and induces autophagy-dependentcell death.Oncotarget, 2016, 7(18):25652-25657 ?(通讯作者)IF:5.008 　 　

11.? Zhen Li , Ke Jiang , Xiaofang Zhu , Guibin Lin , Fei Song , Yongfu Zhao ,Yongjun Piao, Jiwei Liu , Wei Cheng , Xiaolin Bi , Peng Gong , Zhiqi Song , Songshu Meng .Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett, ?2016,370(2):332-44. doi: 10.1016/j.canlet.2015.11.015. Epub 2015 Nov 14. ?（IF:5.992） 　 　

12.? Liu P, Bao H, Zhang X, Zhang J, Ma L, Wang Y, Li C, Wang Z, Gong P*. Better operative outcomes achieved with the prone jackknife vs. lithotomy position during abdominoperineal resection in patients with low rectal cancer.World J Surg Oncol. 2015 Feb 12;13:39. doi: 10.1186/s12957-015-0453-5.PMID:25889121 （1.2） 　 　

13.? Zhang X, Ma L, Bao H, Zhang J, Wang Z, Gong P*.Clinical, pathological and prognostic characteristics of gastroenteropancreatic neuroendocrine neoplasms in China: a retrospective study.BMC Endocr Disord. 2014 Jul 8;14(1):54. （IF：1.673） 　 　

14.? Zhang X , Ma L , Gao X , Bao H , Liu P , Aziz A , Wang Z , Gong P * Pancreaticogastrostomy versus pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: a meta-analysis of randomized controlled ?trials. Surg Today，2014 Sep 26. [Epub ahead of print]PMID:25256939[PubMed - as supplied by publisher] （IF：1.208） 　 　

15.? Zhao S, Wang Y, Gao C, Zhang J, Bao H, Wang Z, Gong P*. Superparamagnetic iron oxide magnetic nanomaterial-labeled bone marrow mesenchymal stem cells for rat liver repair after hepatectomy. J Surg Res. 2014 Mar 27. pii: 0022-4804(14)00344-8. doi: 10.1016/j.jss.2014.03.064. （IF：2.121） 　 　

16.? Gong P*, Wang Y, Zhang J, Wang Z. Differential hepatic stem cell proliferation and differentiation after partial hepatectomy in rats. Mol Med Rep. 2013 Jul 31. doi: 10.3892/mmr.2013.1606. [Epub ahead of print] PubMed PMID: 23903957. (IF: 1.17) 　 　

17.? Gong P*, Zhang X, Zhang J, Zhang J, Luo H, Wang Z. Hepatitis B virus X protein in the proliferation of hepatocellular carcinoma cells. Front Biosci (Landmark Ed). 2013 Jun 1;18:1256-65. PubMed PMID: 23747881. (IF:4.249) 　 　

18.? Gong P*, Wang Y, Zhang J, Wang Z. Bone marrow mesenchymal stem cells in hepatocellular carcinoma. Front Biosci (Landmark Ed). 2013 Jun 1;18:811-9. PubMed PMID: 23747849. (IF:4.249) 　 　

19.? Gong P*, Wang Y, Wang Y, Jin S, Luo H, Zhang J, Bao H, Wang Z. Effect of bone marrow mesenchymal stem cells on hepatocellular carcinoma in microcirculation.Tumor Biol. 2013 ?Aug;34(4):2161-8. doi: 10.1007/s13277-013-0749-4. Epub 2013 Apr 13. PubMed PMID: 23584896. (IF: 2.84) 　 　

20.? Gong P*, Wang Y, Liu G, Zhang J, Wang Z. New insight into Ki67 expression at the invasive front in breast cancer. PLoS One. 2013;8(1):e54912. doi:10.1371/journal.pone.0054912. Epub 2013 Jan 31. PubMed PMID: 23382998; PubMed Central PMCID: PMC3561452. ?(IF:4.092) 　 　

21.? Peng Gong*, Haibo Xu, Jianing Zhang, Zhongyu Wang.PPAR Expression and its Association with SOD and NF-κB in Rats with Obstructive Jaundice. Biomed Res- India2012;23(4) : 551-560. 影响因子0.119 　 　

22.? Gong P*, Wang ZY, Wang HJ. Protective effects of pLNCX-SOD gene transfection on hepatocyte injury induced by obstructive jaundice in rats. Hepatobiliary Pancreat Dis Int. 2007 Apr;6(2):194-8. PubMed PMID: 17374581. IF:1.16 　 　

23.? Jiang K, Liu M, Lin G, Mao B, Cheng W, Liu H, Gal J, Zhu H, Yuan Z, Deng W et al: Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death. Oncotarget 2016.（IF=6.359） 　 　

24.? Li Z, Jiang K, Zhu X, Lin G, Song F, Zhao Y, Piao Y, Liu J, Cheng W, Bi X et al: Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer letters 2016, 370(2):332-344. （IF=5.621） 　 　

25.? Lv L, Wei M, Lin P, Chen Z, Gong P, Quan Z, Tang Z. Integrated mRNA and lncRNAexpression profiling for exploring metastatic biomarkers of human intrahepaticcholangiocarcinoma. Am J Cancer Res. 2017 Mar 1;7(3):688-699. eCollection 2017.PubMed PMID: 28401021; PubMed Central PMCID: PMC5385652. 　 　

26.? Lin ZK, Liu J, Jiang GQ, Tan G, Gong P, Luo HF, Li HM, Du J, Ning Z, Xin Y,Wang ZY. Osthole inhibits the tumorigenesis of hepatocellular carcinoma cells.Oncol Rep. 2017 Mar;37(3):1611-1618. doi: 10.3892/or.2017.5403. Epub 2017 Jan 24.PubMed PMID: 28184928