BIOGRAPHICAL SKETCH 　 　

NAME: Li, Xiaowu ???????????????????????????????Email： lixw1966@163.com ?????????????????????????Tel：+86-13883065936 　 　

POSITION TITLE: MD, Ph.D, Chief Physician, Professor, Chief of Department of Hepatobiliary Surgery, General Hospital of Shenzhen University 　 　

EDUCATION/TRAINING 　 　

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INSTITUTION AND LOCATION	DEGREE	Completion Date	FIELD OF STUDY
West China University of Medical Sciences, Sichuan, China	M.D.	07/1985	Forensic Medicine
West China University of Medical Sciences, Sichuan, China	Ph.D. 　 　 Postgraduate Research	07/1994	Oncology
The First Clinical Teaching Hospital, Beijing Medical University	Postdoctoral Fellow	06/1997	Oncology
The Department of Laboratory Center, The Second Clinical Teaching Hospital, Beijing Medical University	Assistant Professor	02/1998	Oncology
Department of Stomatology, University of California, San Francisco	Postdoctoral Fellow	02/2001	Oncology
Department of Stomatology, University of California, San Francisco	Postgraduate Research	02/2002	Oncology
Department of Stomatology, University of California, San Francisco	Assistant Biologist	0 5/2004	Oncology

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A.? Personal Statement 　 　

The research of our team have always been focusing on the mechanism of tumor cell metastasis, including special extracellular matrix proteins involved in the regulation of tumor cell invasion and metastasis, molecular signaling pathways of tumor cell metastasis regulated by the specific cell surface receptors and the mechanism of tumor hematogenous metastasis promoted by platelets participating in the formation of tumor thrombus. Our research has been continuously supported by the National Natural Science Foundation in China (NSFC) with 3 regular grants and 1 key grants, 2 key grants of Natural Science Fund Project of Chongqing, 1 sub-grant of National 863 Project of China and 1 sub-grant of National Basic Research Program of China since 2004. Our team have published more than 60 papers in the peer-reviewed professional journals and I have mentored about 15 postgraduates (10 PhD and 5 MSc). 　 　

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B.? Positions and Honors 　 　

Positions and Employment 　 　

S ep 2017-Now ?????????Chief Physician, Professor ? of Institute of Hepatobiliary Surgery , Chief of Department of Hepatobiliary Surgery, General Hospital of Shenzhen University 　 　

Jun 2004-Sep 2017 ??Chief Physician, Professor of Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University 　 　

Jun 2003-May 2004 ??Visiting Professor of Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University 　 　

Mar 2002-May 2004 ??Assistant Biologist at Department of Stomatology, University of California, San Francisco 　 　

Mar 2001-Feb 2002 ??Postgraduate Research, Department of Stomatology, University of California, San Francisco 　 　

Mar 1998-Feb 2001 ??Postdoctoral Fellow, Department of Stomatology, University of California, San Francisco 　 　

Feb 1997-Feb 1998 ??Assistant Professor, The Department of Laboratory Center, The Second Clinical Teaching Hospital, Beijing Medical University 　 　

Nov 1994-Jan 1997 ??Postdoctoral Fellow, Surgical Molecular Colorectal Cancer Laboratory, The First Clinical Teaching Hospital, Beijing Medical University 　 　

Sep 1989-Jul 1994 ??Postgraduate Research, Department of Surgical Oncology, The First Hospital of West China University of Medical Sciences 　 　

Other Experience and Honors 　 　

1.? 2014 Military Medical Achievement Award 　 　

2.? 2011 Chongqing Science and Technology Progress Award 　 　

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C.? Contributions to Science ?(*: corresponding/co-corresponding author) 　 　

A full list of my publications (in a total of 66) is enclosed at the end of this document. 　 　

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1.? TN-c involved in the regulation of pancreatic cancer cell invasion and metastasis 　 　

Interaction of cancer cells with stroma cells ? facilitates tumor progression by rebuilding the existing extracellular matrix (ECM) microenvironment. In the tumor, ? upregulation of Tenascin-C (Tn-C) expression potentially can ? alter tumor behavior. However, the molecular mechanisms ? by which tumor-stroma interactions affect the tumor microenvironment have not been well characterized. We found that fTn-C was ? increased in metastatic pancreatic cancer. The fTn-C expression ? correlated with MMP-2 activity. Tn-C ? deposition into the ECM requires participation of active ? MMP-2 and SF. The deposited Tn-C could promote pancreatic ? cancer progression. 　 　

1)? He Y, Liu XD, Chen ZY, Zhu J, Xiong Y, Li K, Dong JH, Li XW* . Interaction between cancer cell and stromal fibroblasts is required for activation of the upar-upa-mmp-2 cascade in pancreatic cancer metastasis.Clin Cancer Res.2007;13(11):3115-3124. 　 　

2)? Chen J, Chen Z, Chen M, Li D, Li ZH, Xiong Y, DONG JH, Li XW* . Role of fibrillar Tenascin-C in metastatic pancreatic cancer. Int. J. Onco 2009; 34: 1029-1036. 　 　

3)? Xu Y, Li Z, Jiang P, Wu G, Chen K, Zhang X, Li X* . The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer. Diagn Pathol. 2015 Dec 10;10:211. 　 　

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2.? Roles of Fyn in pancreatic cancer metastasis 　 　

Compelling evidence indicates that the deregulation of several signaling molecules is associated with progression of pancreatic ? cancer. Of these signaling molecules, the non-receptor-tyrosine ? kinase, c-Src, is overexpressed in 70% of human pancreatic cancers ? and its activity is an important property of tumor progression. Fyn, a critical member of the SFK family mediates a variety of cellular processes, including T-cell receptor ? signaling, regulation of brain function and adhesion-mediated ? signaling. Our study showed that activation of Fyn ? promotes cell proliferation and metastasis in pancreatic cancer and Fyn requires ? HnRNPs and SR proteins to coordinate and regulate splicing of Bcl-x and ?integrin β 1 ?in pancreatic ? cancer cells, thus ? promoting the proliferation and metastasis of pancreatic cancer. 　 　

1)? Chen ZY, Cai L, Bie P, Wang SG, Jiang Y, Dong JH and Li XW* . Roles of Fyn in pancreatic cancer metastasis. J Gastroenterol Hepatol 2010; 25(2):293-301. 　 　

2)? Chen ZY, Cai L, Zhu J, Chen M, Chen J, Li ZH, Liu XD, Wang SG, Bie P, Jiang P, Dong JH, Li XW* . Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis. 2011 Oct;32(10):1419-26. 　 　

3)? Jiang P, Li Z, Tian F, Li X* , Yang J. Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin β1. Int J Oncol. 2017, 51(1):169-183. 　 　

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3.? Tumor-derived exosomal promoted pancreatic cancer metastasis 　 　

Tumor exocrine promoting tumor metastasis has become a new growth point in cancer research in recent years. We found that pancreatic cancer cells can promote the invasion and metastasis of pancreatic cancer by secreting specific tumor exosomes through a variety of pathways: non-coding RNA carried in the exosome acts both on tumor cells to promote cell phenotypic transition enhances tumor invasion and on endothelial cells to regulate cell adhesion and promote tumor metastasis. 　 　

1)? Li Z, Jiang P, Li J, Peng M, Zhao X, Zhang X, Chen K, Zhang Y, Liu H, Gan L, Bi H, Zhen P, Zhu J, Li X* . Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma. Oncogene. 2018, 37(28):3822-3838. 　 　

2)? Zhonghu Li, Wu Yanfang, Jie Li, Peng Jiang, Tao Peng, Kai Chen, Xin Zhao, Yujun Zhang, Ping Zhen, Jin Zhu, Xiaowu Li* . Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Lett. 2018，432:237-250. 　 　

3)? Jie Li, Zhonghu Li, Peng Jiang, Minjie Peng, Xi Zhang, Kai Chen, Hui Liu, Huaqiang Bi, Xiangde Liu, Xiaowu Li* . Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to pr omote tumor metastasis. J Exp Clin Cancer Res，2018 , 37 (1) :177. ? 　 　

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D.? Research Support 　 　

Ongoing Research Support 　 　

National Natural Science Foundation of China (NSFC) Grant (81430063) ????????????from Jan 2015 to Dec 2019 　 　

Xiaowu ? Li , PI ?????????????????????????????????????????????????? ￥ 3,200,000.00 (direct cost) 　 　

The role of tumor embolus microenvironment constructed by TN-c and Periostin in pancreatic cancer hematogenous metastasis. 　 　

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Completed Research Support 　 　

National Natural Science Foundation of China (NSFC) Grant (81272363 ) ???????????????????from Jan 2013 to Dec 2016 　 　

Xiaowu Li, PI ￥650,000.00 (direct cost) 　 　

The molecule mechanism of alternative splicing of CD44 regulated by phosphorylation of Fyn. 　 　

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Natural Science Fund Project of Chongqing Grant (2012JB1032) ??????????????????????????from Jan 2012 to Dec 2015 　 　

Xiaowu Li, PI ￥200,000.00 　 　

Hematogenous metastasis of pancreatic cancer regulated by Fyn activity 　 　

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National 863 Project of China Grant（2012AA02A201） ?????????????????????????????? ?from Jan 2010 to Dec 2011 　 　

Xiaowu Li, PI ￥970,000.00 　 　

Genomics of liver metastasis in pancreatic cancer. 　 　

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National Basic Research Program of China (973 Program) Grant (2010CB529406) ????????????from Jan 2010 to Dec 2015 　 　

Xiaowu Li, PI ???????????????????????????????????????????? ??????￥1,000,000.00 　 　

A new method of tumor therapy targeting iCSCs and vascular endothelial growth factor 　 　

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Agency: National Natural Science Foundation of China (NSFC) Grant (30872497) ????????????from Jan 2009 to Dec 2011 　 　

Xiaowu Li, PI ?????????????????????????????????? ??????￥380,000.00 　 　

Mechanism of integrin β1 splicing regulated by Fyn-hnRNP E1 signal in pancreatic cancer 　 　

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Agency: Natural Science Fund Project of Chongqing Grant (CSTC2005BA5022) ???????????????from Jan 2005 to Dec 2008 　 　

Xiaowu Li, PI ????????????????????????????????????????????? ??????￥200,000.00 　 　

Cloning and functional identification of tumor membrane proteins associated with liver metastasis 　 　

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National Natural Science Foundation of China (NSFC) Grant (30371587) ??????????????????????????from Jan 2004 to Dec 2006 　 　

Xiaowu Li, PI ??????????????????????????????????????? ￥200,000.00 　 　

Interference of TN-c organization regulates the metastasis of pancreatic cancer. 　 　

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E.? Peer-reviewed publications (*: corresponding author) 　 　

1.? Feng, K., Yan, J., Li, X., Xia, F., Ma, K., Wang, S., Bie, P., Dong, J. (2012) A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma. J Hepatol, 57, 794-802.F=14.911 　 　

2.? He, Y., Liu, X., Chen, Z., Zhu, J., Xiong, Y., Li, K., Dong, J., Li, X * . (2007) Interaction between Cancer Cells and Stromal Fibroblasts Is Required for Activation of the uPAR-uPA-MMP-2 Cascade in Pancreatic Cancer Metastasis. Clinical Cancer Research, 13, 3115-3124.F=10.199 　 　

3.? Ramos, D.M., But, M., Regezi, J., Schmidt, B.L., Atakilit, A., Dang, D., Ellis, D., Jordan, R., Li, X. (2002) Expression of integrin beta 6 enhances invasive behavior in oral squamous cell carcinoma. Matrix Biol, 21, 297-307.F=8.136 　 　

4.? Li, Z., Jiang, P., Li, J., Peng, M., Zhao, X., Zhang, X., Chen, K., Zhang, Y., Liu, H., Gan, L., Bi, H., Zhen, P., Zhu, J., Li, X * . (2018) Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma. Oncogene, 37, 3822-3838.F=7.932 　 　

5.? Tian, F., Li, D., Chen, J., Liu, W., Cai, L., Li, J., Jiang, P., Liu, Z., Zhao, X., Guo, F., Li, X., Wang, S. (2013) Aberrant expression of GATA binding protein 6 correlates with poor prognosis and promotes metastasis in cholangiocarcinoma. Eur J Cancer, 4 9, 1771-80.F=7.191 　 　

6.? Bordador, L.C., Li, X*., Toole, B., Chen, B., Regezi, J., Zardi, L., Hu, Y., Ramos, D.M. (2000) Expression of emmprin by oral squamous cell carcinoma. International Journal of Cancer Journal International Du Cancer, 85, 347.F=7.36 　 　

7.? Li, Z., Wu, Y., Li, J., Jiang, P., Peng, T., Chen, K., Zhao, X., Zhang, Y., Zhen, P., Zhu, J. ? Xiaowu Li*. ?(2018) Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. Cancer Letters.F=6.491 　 　

8.? Zhang, X., Jiang, P., Shuai, L., Chen, K., Li, Z., Zhang, Y., Jiang, Y., Li, X*. (2016) miR-589-5p inhibits MAP3K8 and suppresses CD90+cancer stem cells in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research Cr, 35, 176.F=6.217 　 　

9.? Li, J., Li, Z., Jiang, P., Peng, M., Zhang, X., Chen, K., Liu, H., Bi, H., Liu, X., Li, X * . (2018) Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor me tastasis. Journal of Experimental & Clinical Cancer Research, 37, 177.F=6.217 　 　

10.? Wu, G., Li, Z., Jiang, P., Zhang, X., Xu, Y., Chen, K., Li, X*. (2017) MicroRNA-23a promotes pancreatic cancer metastasis by targeting epithelial splicing regulator protein 1. Oncotarget, 8, 82854-82871.F=5.168 　 　

11.? Zou, Y., Li, J., Chen, Z., Li, X., Zheng, S., Yi, D., Zhong, A., Chen, J. (2015) miR-29c suppresses pancreatic cancer liver metastasis in an orthotopic implantation model in nude mice and affects survival in pancreatic cancer patients. Carcinogenesis, 36, 676-84.F=5.105 　 　

12.? Chen, Z.Y., Cai, L., Zhu, J., Chen, M., Chen, J., Li, Z.H., Liu, X.D., Wang, S.G., Bie, P., Jiang, P., Dong, J.H., Li, X.W*. (2011) Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis, 32, 1419-26.F=5.105 　 　

13.? He, Q., Cai, L., Shuai, L., Li, D., Wang, C., Liu, Y., Li, X., Li, Z., Wang, S. (2013) Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21. Mol Carcinog, 52, 286-96.F=4.722 　 　

14.? Li, X., Regezi, J., Ross, F.P., Blystone, S., Ilic, D., Leong, S.P., Ramos, D.M. (2001) Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. J Cell Sci, 114, 2665-72.F=4.706 　 　

15.? Liu, H., Jiang, P., Li, Z., Li, X*., Djaker, N., Spadavecchia, J. (2018) HIV-1 Tat Peptide-Gemcitabine Gold (III)-PEGylated Complex-Nanoflowers: A Sleek Thermosensitive Hybrid Nanocarrier as Prospective Anticancer. Particle and Particle Systems Characteriz ation, 35, 1800082. F=4.384 　 　

16.? Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Schmidt, B.L., Atakilit, A., Chen, B., Ellis, D., Ramos, D.M. (2003) Alphavbeta6-Fyn signaling promotes oral cancer progression. J Biol Chem, 278, 41646-53.F=4.258 　 　

17.? Xia, F., Lau, W.Y., Qian, C., Ma, K., Li, X., Bie, P. (2011) Continuous occlusion of hepatic artery proper for prevention of blood loss in partial hepatectomy for ruptured hepatocellular carcinoma: a case-matched comparative study. Ann Surg Oncol, 18, 1638 -43.F=4.041 　 　

18.? Xia, F., Lai, E.C., Lau, W.Y., Ma, K., Li, X., Bie, P., Qian, C. (2012) High serum hyaluronic acid and HBV viral load are main prognostic factors of local recurrence after complete radiofrequency ablation of hepatitis B-related small hepatocellular carcino ma. Ann Surg Oncol, 19, 1284-91.F=4.041 　 　

19.? Zhao, X., Jiang, P., Deng, X., Li, Z., Tian, F., Guo, F., Li, X., Wang, S. (2016) Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress. Am J Cancer Res, 6, 2289-2298.F=3.998 　 　

20.? Liu, Y.K., Li, Z.H., Liu, N.Z., He, Q., Lin, H., Wang, X.J., Li, X.W., Dong, J.H. (2010) Reduced myoelectric activity in the sphincter of Oddi in a new model of chronic cholangitis in rabbits: an in vivo and in vitro study. Neurogastroenterology & Motility , 22, 927-e239.F=3.842 　 　

21.? Chen, F., Chen, J., Dong, J.H., Chen, M., Li, H.C., Li, X.W., Li, Z.H. (2009) The feasibility and reliability of using circular electrode for sphincter of Oddi electromyography in anaesthetised rabbits. Neurogastroenterol Motil, 21, 651-6, e28-9.F=3.842 　 　

22.? Song, J., Wang, Y., Ma, K., Zheng, S., Bie, P., Xia, F., Li, X., Li, J., Wang, X., Chen, J. (2016) Laparoscopic hepatectomy versus radiofrequency ablation for minimally invasive treatment of single, small hepatocellular carcinomas. Surg Endosc, 30, 4249-57 .F=3.747 　 　

23.? Chen, Z.Y., Cai, L., Bie, P., Wang, S.G., Jiang, Y., Dong, J.H., Li, X.W. (2010) Roles of Fyn in pancreatic cancer metastasis. Journal of Gastroenterology & Hepatology, 25, 293-301.F=3.483 　 　

24.? Zhang, F., Yan, J., Feng, X.B., Xia, F., Li, X.W., Ma, K.S., Bie, P. (2015) Efficiency and safety of radiofrequency-assisted hepatectomy for hepatocellular carcinoma with cirrhosis: A single-center retrospective cohort study. World J Gastroenterol, 21, 101 59-65.F=3.365 　 　

25.? Xia, F., Wu, L.L., Lau, W.Y., Huan, H.B., Wen, X.D., Ma, K.S., Li, X.W., Bie, P. (2016) Adjuvant sorafenib after heptectomy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma patients. World J Gastroenterol, 22, 5384-92.F=3.365 　 　

26.? Jiang, P., Li, Z., Tian, F., Li, X*., Yang, J. (2017) Fyn/heterogeneous nuclear ribonucleoprotein E1 signaling regulates pancreatic cancer metastasis by affecting the alternative splicing of integrin beta1. Int J Oncol, 51, 169-183.F=3.333 　 　

27.? Chen, J., Chen, Z., Chen, M., Li, D., Li, Z., Xiong, Y., Dong, J., Li, X*. (2009) Role of fibrillar Tenascin-C in metastatic pancreatic cancer. International Journal of Oncology, 34, 1029-1036.F=3.333 　 　

28.? Zhang, L., Huang, G., Li, X., Zhang, Y., Jiang, Y., Shen, J., Liu, J., Wang, Q., Zhu, J., Feng, X., Dong, J., Qian, C. (2013) Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular ca rcinoma. BMC Cancer, 13, 108.F=3.288 　 　

29.? Yan, J., Qian, L., Dong, J., Li, X., Ma, K., Lei, C. (2012) Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation. BMC Cancer,12,1(2012-08-15), 12, 353.F=3.288 　 　

30.? Xu, J., Li, D., Li, X., Liu, Z., Li, T., Jiang, P., He, Q., Tian, F., Gao, Y., Wang, D., Wang, S. (2014) 67 laminin receptor promotes the malignant potential of tumour cells up-regulating lysyl oxidase-like 2 expression in cholangiocarcinoma. Dig Liver Dis , 46, 750-7.F=3.287 　 　

31.? Deng, Q., Zhang, Z., Feng, X., Li, T., Liu, N., Lai, J., Shuai, L., Xiong, Q., Fu, C., Zou, H., Wang, Y., Li, X., Ma, K., Bie, P. (2014) TRAIL-secreting mesenchymal stem cells promote apoptosis in heat-shock-treated liver cancer cells and inhibit tumor gro wth in nude mice. Gene Ther, 21, 317-27.F=3.242 　 　

32.? Zhu, J., Wang, S., Bie, P., Li, X., Zhang, Y., Xiong, Y., Wang, H., Ma, Z., Li, K., Dong, J. (2007) Apoptosis and regeneration of sinusoidal endothelial cells after extended cold preservation and transplantation of rat liver. Transplantation, 84, 1483-91.F=3.96 　 　

33.? Tian, F., Cheng, L., Li, D., Liu, Z., Zeng, Y., Xu, J., Li, X., Wang, S. (2011) Downregulation of mucins in graft bile ducts after liver transplantation in rats. Transplantation, 92, 529-35.F=3.96 　 　

34.? Cheng, L., Zhao, L., Li, D., Liu, Z., Chen, G., Tian, F., Li, X., Wang, S. (2010) Role of cholangiocyte bile Acid transporters in large bile duct injury after rat liver transplantation. Transplantation, 90, 127-34.F=3.96 　 　

35.? Chen, G., Wang, S., Bie, P., Li, X., Dong, J. (2009) Endogenous bile salts are associated with bile duct injury in the rat liver transplantation model. Transplantation, 87, 330-9.F=3.96 　 　

36.? Wang, Q., Yan, J., Feng, X., Chen, G., Xia, F., Li, X., Ma, K., Bie, P. (2017) Safety and efficacy of radiofrequency-assisted ALPPS (RALPPS) in patients with cirrhosis-related hepatocellular carcinoma. Int J Hyperthermia, 33, 846-852.F=3.44 　 　

37.? Tang, T., Feng, X., Yan, J., Xia, F., Li, X., Ma, K., Bie, P. (2014) Predictive value of indocyanine green retention rate with respect to complications of radiofrequency ablation in 878 patients with hepatocellular carcinoma. Int J Hyperthermia, 30, 402-7. F=3.44 　 　

38.? Liu, N., Gao, J., Liu, Y., Li, T., Feng, K., Ma, K., Dong, J., Li, X., Wang, S., Bie, P. (2012) Determining a minimal safe distance to prevent thermal injury to intrahepatic bile ducts in radiofrequency ablation of the liver: a study in dogs. Int J Hyperth ermia, 28, 210-7.F=3.44 　 　

39.? Feng, X., Su, Y., Zheng, S., Xia, F., Ma, K., Yan, J., Li, X., Tang, W., Wang, S., Bie, P., Dong, J. (2017) A double blinded prospective randomized trial comparing the effect of anatomic versus non-anatomic resection on hepatocellular carcinoma recurrence. ?HPB (Oxford), 19, 667-674.F=3.29 　 　

40.? Zhao, X., Guo, F., Li, Z., Jiang, P., Deng, X., Tian, F., Li, X., Wang, S. (2016) Aberrant expression of B7-H4 correlates with poor prognosis and suppresses tumor-infiltration of CD8+ T lymphocytes in human cholangiocarcinoma. Oncol Rep, 36, 419-27.F=2. 976 　 　

41.? Chen, K., Li, Z., Jiang, P., Zhang, X., Zhang, Y., Jiang, Y., He, Y., Li, X*. (2014) Co-expression of CD133, CD44v6 and human tissue factor is associated with metastasis and poor prognosis in pancreatic carcinoma. Oncology Reports, 32, 755-763.F=2.976 　 　

42.? Duan, S.G., Cheng, L., Li, D.J., Zhu, J., Xiong, Y., Li, X.W*., Wang, S.G. (2010) The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells. Dig Dis Sci, 55, 2844-52.F=2.875 　 　

43.? Yang, Y., Dang, D., Atakilit, A., Schmidt, B., Regezi, J., Li, X., Eisele, D., Ellis, D., Ramos, D.M. (2003) Specific alpha v integrin receptors modulate K1735 murine melanoma cell behavior. Biochem Biophys Res Commun, 308, 814-9.F=2.559 　 　

44.? Yang, S.Z., Zhang, L.D., Zhang, Y., Xiong, Y., Zhang, Y.J., Li, H.L., Li, X.W., Dong, J.H. (2009) HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line. Biochemical & Biophysical Research Communications, 382, 555-560.F=2.559 　 　

45.? Xue, H., Atakilit, A., Zhu, W., Li, X., Ramos, D.M., Pytela, R. (2001) Role of the alpha(v)beta6 integrin in human oral squamous cell carcinoma growth in vivo and in vitro. Biochem Biophys Res Commun, 288, 610-8.F=2.559 　 　

46.? Yang, Z.Q., Yang, Z.Y., Zhang, L.D., Ping, B., Wang, S.G., Ma, K.S., Li, X.W., Dong, J.H. (2010) Increased liver-infiltrating CD8+FoxP3+ regulatory T cells are associated with tumor stage in hepatocellular carcinoma patients. Hum Immunol, 71, 1180-6.F=2 .311 　 　

47.? Wu, Q., Tang, C., Zhang, Y.J., Jiang, Y., Li, X.W., Wang, S.G., Bie, P. (2011) Diazoxide suppresses hepatic ischemia/reperfusion injury after mouse liver transplantation by a BCL-2-dependent mechanism. J Surg Res, 169, e155-66.F=2.198 　 　

48.? Liu, W., Tian, F., Jiang, P., Zhao, X., Guo, F., Li, X., Wang, S. (2014) Aberrant expression of laminin gamma2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma. J Surg Res, 186, 150-6.F=2.198 　 　

49.? Li, T., Zhu, J., Ma, K., Liu, N., Feng, K., Li, X., Wang, S., Bie, P. (2013) Autologous bone marrow-derived mesenchymal stem cell transplantation promotes liver regeneration after portal vein embolization in cirrhotic rats. J Surg Res, 184, 1161-73.F=2. 198 　 　

50.? Li, Z., Zhao, X., Jiang, P., Xiao, S., Wu, G., Chen, K., Zhang, X., Liu, H., Han, X., Wang, S., Li, X * . (2016) HBV is a risk factor for poor patient prognosis after curative resection of hepatocellular carcinoma: A retrospective case-control study. Medicine ?(Baltimore), 95, e4224.F=2.133 　 　

51.? Cai, L., Han, J., Zhuo, X., Xiong, Y., Dong, J., Li, X*. (2009) Overexpression and significance of focal adhesion kinase in hepatocellular carcinoma and its relationship with HBV infection. Medical Oncology, 26, 409-414.F=2.92 　 　

52.? Dang, D., Yang, Y., Li, X., Atakilit, A., Regezi, J., Eisele, D., Ellis, D., Ramos, D.M. (2004) Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. Biochem Biophys Res Commun, 316, 937-42.F=2.59 　 　

53.? Wang, C., Zhang, L., He, Q., Feng, X., Zhu, J., Xu, Z., Wang, X., Chen, F., Li, X*., Dong, J. (2012) Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma. Molecular Medicine Reports, 5, 410-414.F=1.922 　 　

54.? Pan, S., Li, X*., Jiang, P., Jiang, Y., Shuai, L., He, Y., Li, Z. (2015) Variations of ABCB4 and ABCB11 genes are associated with primary intrahepatic stones. Molecular Medicine Reports, 11, 434.F=1.922 　 　

55.? Feng, X., Song, P., Bie, P., Jiang, P., Ma, K., Li, X., Wang, S., Wang, Z., Tang, W., Zheng, S. (2016) Des-gamma-Carboxyprothrombin Plasma Level in Diagnosis of Hepatocellular Carcinoma in a Chinese Population Undergoing Surgery. Med Sci Monit, 22, 1663-72 .F=1.894 　 　

56.? Guo, R., Feng, X., Xiao, S., Yan, J., Xia, F., Ma, K., Li, X * . (2015) Short- and long-term outcomes of hepatectomy with or without radiofrequency-assist for the treatment of hepatocellular carcinomas: a retrospective comparative cohort study. Bioscience Tre nds, 9, 65-72.F=1.844 　 　

57.? Zhang, Z., Zhuang, Z., Xu, Z., Mei, Q., Ma, K., Li, X., Bie, P. (2014) Post-operative pericardial effusion following treatment of small hepatocellular carcinoma with radiofrequency ablation: A case report. Oncol Lett, 7, 345-348.F=1.664（* 通讯作者） 　 　

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