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A.?? Personal Statement

My research interests are on the isolation, structural characterization, biological evaluation, structural optimization, and mechanistic exploration of natural products produced by insects, Ganoderma fungi, and plant resins. I have focused on compounds with potential reno-protective and neuro-protective effects inspired by traditional Chinese medicine philosophy or bionic concepts. In particular, I made great progress on nonpeptide small molecules from the insects and aromatic meroterpenoids from Ganoderma fungi, which represents pioneering work in this field. Given these achievements, I was supported by the National Science Fund for Distinguished Young Scholars in China. My future research will utilize biotic and abiotic stressors, such as light induction, to create chemical and biological diversities of metabolites from the above materials. Under the support of projects such as National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Eleventh and Twelfth Five-year Plan Periods, NSFC-Joint Foundation of Yunnan Province, National Natural Science Foundation of China, Knowledge Innovation Project of the Chinese Academy of Sciences, and West Light Foundation of the Chinese Academy of Sciences, I have published 200 papers (e.g. JASN, Org Lett, J Nat Prod) and appliedfor 67 patents. I am currently mentoring two PhD candidates and 11 MSc candidates.

B.?? Positions and Honors

Positions and Employment

10/2002–07/2003 Reviewer, Center for Drug Evaluation, China Food and Drug Administration, Beijing, China

03/2005–08/2016? Professor, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, China

09/2016–present? Vice Director, Guangdong Key Laboratory for Genome Stability & Disease Prevention; Vice Dean, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen, China

Organizing International Meetings

1.??? Organizer, The 15th National Conference on Medicinal Plants and Phytomedicines, July 20-22th, 2017, Shenzhen

Other Experience and Honors

1. Honorary President of College of Pharmaceutical Sciences, Yunnan University

?of Traditional Chinese Medicine, Kunming, China: 2017-present

2. NSFC Final Review Expert (Traditional Chinese Medicine): 2016, 2017

3. Editorial Board Member, Natural Product Research and Development: 2016-present

4. The second award of National Scientific and Technological Progress: 2016 (8th)

5. The first prize in Chinese Medical Science and Technology: 2015 (5th)

6. The first prize in Scientific and Technological Progress in Guangdong province:

2012 (3rd)

7. The first prize in Natural Science of Yunnan province: 2006 (7th)

8. Alexander von Humboldt Research Fellow: 2003-present

C.?? Contributions to Science (*: corresponding/co-corresponding author)

A full list of my publications is enclosed at the end of this document

1.????? Bioactive compounds from medicinal resins

Resins are secreted by many plants, and their biological effects and defensive roles in the plants have been documented. For example, Gambogic acid is a xanthonoid derived from the resin of Garcinia hanburyi, and is well known for its profound antitumor activity in clinical trials. Resina Toxicodendri (ResT) is the dried medicinal resin produced by T. vernicifluum. ResT is used as a Chinese medicine for promoting blood circulation and removing blood stasis and always occurs in prescriptions of Chinese medicine. We hypothesized that ResT might contain compounds that are beneficial for microvascular-associated diseases, such as diabetic nephropathy and renal fibrosis. With this motivation, renoprotective compounds targeting the TGF-β1/Smad signaling pathway were characterized. Our study revealed that GQ5 could be a promising drug lead for developing an effective anti-fibrotic remedy. Structural optimization of GQ5 is undergoing.

1) Jun Ai, Jing Nie, Jiang-Bo He, Qin Guo, Mei Li, Ying Lei, Youhua Liu, Zhan-Mei Zhou, Feng-Xin Zhu, Min Liang, Yong-Xian Cheng*, Fan-Fan Hou*. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-induced Smad3 Phosphorylation. Journal of the American Society of Nephrology 2015, 26, 1827–1838.

2) Jiang-Bo He, Jie Luo, Li Zhang, Yong-Min Yan, Yong-Xian Cheng*. Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors. Organic Letters 2013, 15, 3602–3605.

3) Jia-Wang Liu, Ying Liu, Yong-Ming Yan, Jing Yang, Xi-Feng Lu*, Yong-Xian Cheng*. Commiphoratones A and B, Two Sesquiterpene Dimers from Resina Commiphora. Organic Letters 2018 (in press).

4) Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu*, and Yong-Xian Cheng*.Characterization of Sesquiterpene Dimers from Resina Commiphora that Promote Adipose-Derived Stem Cell Proliferation and Differentiation. The Journal of Organic Chemistry 2018, 83, 2725-2733.

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2.????? Nonpeptidal small molecules from the medicinal insects

Insects are the most diverse and abundant of all terrestrial animals. While the crucial role that insects have in the ecosystem has received great attention, studies of the chemical defense mechanisms used by insects began only in the late 1950s. Since the inception of these efforts, several structurally interesting small molecules, which are utilized as defensive substances, have been discovered. However, in contrast to efforts exploring their species diversity and richness, as well as their peptide components, much less attention has been given to non-peptidal chemical substances that insects employ to combat natural enemies or maintain their physiological activities. To an even greater extent, the potential roles that insect-derived substances might have as lead compounds in drug discovery efforts has been largely ignored. Insects are utilized as medicines or foods in some cultures of the world, especially China. The insect, Aspongopus chinensis Dallas (Pentatomidae) is an endemic food and medicinal food found mainly in southern China. The dried body of A. chinensis, is a common traditional Chinese medicine utilized to treat pain, poor digestion and kidney diseases: Yang has effects on promoting the flow of Qi, warming the stomach, relieving pain and restoring the kidney. We thus undertook an investigation on this insect and characterized >100 small molecules including novel natural product hybrids. We then assessed the biological activities of these molecules on renal protection. Understanding the mechanisms underlying the formation of hybrids in A. chinensis and compounds from the other medicinal insects is undergoing.

1)??? Yong-Ming Yan, Jun Ai, Yan-Ni Shi, Zhi-Li Zuo, Bo Hou, Jie Luo, Yong-Xian Cheng*. (±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3. Organic Letters 2014, 16, 532?535.

2)??? Lei Di, Yan-Ni Shi, Yong-Ming Yan, Li-Ping Jiang, Bo Hou, Xin-Long Wang, Zhi-Li Zuo,* Yong-Bin Chen, Cui-Ping Yang* and Yong-Xian Cheng*. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties. RSC Advances 2015, 5, 70985–70991.

3)??? Jian-Jun Tang, Li Zhang, Li-Ping Jiang, Lei Di, Yong-Ming Yan, Zheng-Chao Tu*, Cui-Ping Yang, Zhi-Li Zuo, Bo Hou, Hou-Lin Xia, Yong-Bin Chen*, Yong-Xian Cheng*. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation. Tetrahedron 2014, 70, 8852–8857.

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3.????? Structurally diverse meroterpenoids from the fungal Ganoderma

Ganoderma species are a collection of mushrooms that are mainly found in tropical regions. Several species in this genus are of medicinal value and have been used as famous traditional Chinese medicines for centuries. Amongst these important species is Ganoderma lucidum, also named G. lingzhi, which has attracted great attention for decades. In 2009, we initiated an investigation on G. lucidum, and reported the first reno-protective meroterpenoid enantiomers (lingzhiols) in 2013. We have since described a number of structurally diverse meroterpenoids from G. lucidum or the other Ganoderma species with reno-protective or neuro-protective activities. These findings not only add new facets for the compound classes in the genus Ganoderma, but also imply that there is a biosynthetic pathway responsible for generating a pool of such diverse meroterpenoids, which might arouse great interest in the biochemistry field. Thus far, the total synthesis of lingzhiols has been successfully performed. In the future, we will use fermentation and/or biotic and abiotic stress to induce Ganoderma fungi to generate structurally and biologically diverse compounds and explore their roles in the intervention of chronic disorders.

1)??? Feng-Jiao Zhou, Yin Nian, Yong-Ming Yan, Ye Gong, Qi Luo, Yu Zhang, Bo Hou, Zhi-Li Zuo, Shu-Mei Wang, He-Hai Jiang, Jian Yang*, Yong-Xian Cheng*. Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear. Organic Letters 2015, 17, 3082–3085.

2)??? Qi Luo, Lei Tian, Lei Di,Yong-Ming Yan, Xiao-Yi Wei, Xin-Fang Wang, and Yong-Xian Cheng*. (±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Potent Smad3 Phosphorylation Inhibition from Ganoderma sinensis. Organic Letters 2015, 17, 1565-1568.

3)??? ?Qi Luo, Lei Di, Wei-Feng Dai, Qing Lu, Yong-Ming Yan, Zhu-Liang Yang, Rong-Tao Li, and Yong-Xian Cheng*.Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum that Displays Potent Antifibrotic Activity. Organic Letters 2015, 17, 1110?1113.

4)??? ?Man Dou, Lei Di, Li-Li Zhou, Yong-Ming Yan, Xin-Long Wang, Feng-Jiao Zhou, Zhu-Liang Yang,Rong-Tao Li*, Fan-Fan Hou,* and Yong-Xian Cheng*. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.Organic Letters 2014, 16, 6064–6067.

5)??? ?Yong-Ming Yan, Jun Ai, Li-Li Zhou, Arthur C.K. Chung, Rong Li, Jing Nie, Ping Fang, Xin-Long Wang, Jie Luo, Qun Hu, Fan-Fan Hou*, Yong-Xian Cheng*. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum. Organic Letters 2013, 15, 5488–5491.

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D.?? Research Support

Ongoing Research Support

NSFC-Joint Foundation of Yunnan Province (U1702287), 01/01/2018 to 12/31/2021

Yongxian Cheng, PI?????????????????????? ￥2,040,000

Characterization of active compounds from Ganoderma species produced in Yunnnan province targeting insulin resistance and their action mechanism investigation

National Key Research and Development Program of China (2017YFD0201402),? 01/01/2017 to 12/31/2020

Yongxian Cheng, PI of Topic II???????????? ￥3,000,000

Natural product library construction targeting microorganisms

National Key Research and Development Program of China (2017YFA0503900), 01/01/2017 to 12/31/2021

Yongxian Cheng, Participant?????????????? ￥3,000,000

Natural product library construction targeting tumor

Shenzhen Science and Technology Innovation Commission grant (JCYJ20170412110504956), 07/01/2017 to 06/30/2020

Yongxian Cheng, PI?????????????????????? ￥2,500,000

Nonpeptide small molecules from medicinal insects and investigation on their

druggability properties

National Science Fund for Distinguished Young Scholars (81525026)??? 01/01/2016 to 12/31/2020

Yongxian Cheng, PI??????????????????????? ￥4,000,000

Unveiling the scientific implications of Chinese materia medica via discovery of bioactive compounds

National Natural Science Foundation of China (21472199), 01/01/2015 to 12/31/2018

Yongxian Cheng, PI?????????????????????? ??￥880,000

Reno-protective meroterpenoids from Ganoderma fungi and their molecular mechanism on TGF-β/Smads signaling pathway

Completed Research Support

NSFC-Joint Foundation of Yunnan Province (U1202222), 01/01/2013 to 12/31/2016

Yongxian Cheng, PI???????????????????? ????￥2,140,000

Action mechanism, structure optimization, and druggability of GQ5, a leading compound with antifibrotic activity

National Natural Science Foundation of China (21172223), 01/01/2012 to 12/31/2015

Yongxian Cheng, PI?????????????????????? ??￥600,000

Isolation, biological evaluation and action mechanism of compounds from the insect Blaps japonensis used by Yi nationality?

National Natural Science Foundation of China (20972165), 01/01/2010 to 12/31/2012

Yongxian Cheng, PI????????????????????? ???￥330,000

NMDA antagonists from Rumex species and their SAR and primary action mechanism investigation

National Natural Science Foundation of China (30700059), 01/01/2008 to 12/31/2010

Yongxian Cheng, PI????????????????????? ???￥160,000

N-containing compounds from Brachystemma calycinum and their immunosuppressant activity and primary action mechanism

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The 12th Five-Year Major New Drug Innovation Project (2012ZX09103201-052), 12/01/2011 to 12/31/2015

Yongxian Cheng, PI?????????????????????? ￥1,432,700

Druggability evaluation of a NMDA receptor antagonist (Rulex) as a new type of anxiolytic drug?

The 11th Five-Year Major New Drug Innovation Project (2008ZX09401-004), 07/01/2010 to 06/30/2011

Yongxian Cheng, co-PI?????????????????????? ￥3,000,000

The construction of research base for innovative drugs on? cerebrovascular

and central nerve system

E.??? Peer-reviewed publications (*: corresponding author)

1.??????????? Yong Luo, Xiao-Zhen Li, Bin Xiang, Qi Luo, Jia-Wang Liu, Yong-Ming Yan, Qin Sun, Yong-Xian Cheng*. Cytotoxic and renoprotective diterpenoids from Clerodendranthus spicatus. Fitoterapia 2018, 125, 135–140.

2.??????????? Xiao-Yu Hu, Fu-Ying Qin, Xi-Feng Lu, Lan-Sheng Zhang*, Yong-Xian Cheng*. Three New Polyynes from Codonopsis pilosula and Their Activities on Lipid Metabolism.Molecules 2018, 23, 887–894.

3.??????????? Ya-Meng Zhao, Yong-Xian Cheng, Yu-Nan Ma, Chuan-Jiao Chen, Fu-Rong Xu*, Xian Dong*. Role of Phenolic Acids from the Rhizosphere Soils of Panax notoginseng as a Double-Edge Sword in the Occurrence of Root-Rot Disease. Molecules 2018, 23, 819–829.

4.??????????? Wu-Mei Sun, Yu-Nan Ma , Yan-Jiao Yin, Chuan-Jiao Chen, Fu-Rong Xu, Xian Dong*, Yong-Xian Cheng*. Effects of Essential Oils from Zingiberaceae Plants on Root-Rot Disease of Panax notoginseng.Molecules 2018, 23, 1021–1031.

5.??????????? Ze-zhi Li, Yanzhi Wang*, MeiLing Gao, Wanhua Cui , Mengnan Zeng, Yongxian Cheng, Juan Li. Nine New Gingerols from the Rhizoma of Zingiber officinale and Their Cytotoxic Activities. Molecules 2018, 23, 315–324.

6.??????????? Shu-juan Xue, Li-li Wang, Sui-qing Chen*, Yong-xian Cheng. Simultaneous Analysis of Saccharides between Fresh and Processed Radix Rehmanniae by HPLC and UHPLC-LTQ-Orbitrap-MS with Multivariate Statistical Analysis.Molecules 2018, 23, 541–559.

7.??????????? Jing-Jing Qi, Yong-Ming Yan, Li-Zhi Cheng, Bao-Hua Liu*, Fu-Ying Qin, , Yong-Xian Cheng*. A Novel Flavonoid Glucoside from the Fruits of Lycium ruthenicun. Molecules 2018, 23, 325–331.

8.??????????? Fu-Ying Qin, Li-Zhi Cheng, Yong-Ming Yan, Bao-Hua Liu, Yong-Xian Cheng*.?????????????????? ??????????????????????

Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula. Molecules 2018, 23, 180–185.

9.??????????? Tao Zheng, Li-Zhi Cheng, Yong-Ming Yan, Bao-Hua Liu, Fu-Ying Qin, Fu-Rong???

Xu*, Yong-Xian Cheng*. Two New Triterpenoids from the Roots of Codonopsis pilosula. Molecules 2018, 23, 383–389.

10.??????????? Qi Luo, Zheng-Chao Tu, Zhu-Liang Yang, Yong-Xian Cheng*. Meroterpenoids from the fruiting bodies of Ganoderma theaecolum. Fitoterapia 2018,125, 273–280.

11.??????????? Tao Zheng, Li-Zhi Cheng, Yong-Ming Yan, Fu-Rong Xu, Xiao-Long Tang, Xiao-Zhen Li, Fu-Ying Qin , Bao-Hua Liu* , Yong-Xian Cheng*. Compounds from the Roots of Codonopsis pilosula and their SIRT1 Regulatory Activity. Natural Product Communications 2018, 13, 1–4.??

12.??????????? Jun-Ming Wang, Li-Xin Pe, Yue-Yue Zhang, Yong-Xian Cheng, Chun-Ling,? NiuYing Cui, Wei-Sheng Feng, Gui-Fang Wang. Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF. Metabolic Brain Disease 2018, 33, 885–892.

13.??????????? Ying-Ying Song, Ying Liu, Yong-Ming Yan, Xi-Feng Lu, Yong-Xian Cheng*. Phenolic Compounds from Belamcanda chinensis Seeds. Molecules 2018, 23, 580–589.

14.??????????? Yong-Ming?Yan, Bin?Xiang, Hong-Jie?Zhu, Jing-Jing?Qi, Bo?Hou, Fu-Neng?Geng, Yong-Xian Cheng*.? N-containing compounds from Periplaneta americana and their activities against wound healing. Journal of Asian Natural Products Research, 2018, 1-10.https://doi.org/10.1080/10286020.2018.1450392

15.??????????? Fu-Ying Qin, Yong-Ming Yan, Zheng-Chao Tu, Yong-Xian Cheng*. ?Cochlearoids L and M: Two New Meroterpenoids from the Fungus Ganoderma cochlear. Natural Product Communications 2018 , 13, 303?305.

16.??????????? Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu, Yong-Xian Cheng*. Characterization of Sesquiterpene Dimers from Resina Commiphora That Promote Adipose-Derived Stem Cell Proliferation and Differentiation. The Journal of Organic Chemistry 2018, 83, 2725?273.

17.??????????? Jia-Wang Liu, Ying Liu, Yong-Ming Yan, Jing Yang, Xi-Feng Lu , Yong-Xian Cheng*. Commiphoratones A and B, Two Sesquiterpene Dimers from Resina Commiphora. Organic Letters2018 , 20, 2220?2223.

18.??????????? Tao Zheng, Yong-Ming Yan, Zheng-Chao Tu, Fu Rong Xu, Yong-Xian Cheng*. Two New Compounds from Medicinal Insect Blaps japanensis and? Their Biological Evaluation . Natural Product Communications 2018, 13, 149–151.

19.??????????? Xiao-Zhen?Li, Li-Zhi?Cheng, Yong-Ming?Yan, Bao-Hua?Liu, Yong-Xian Cheng*. SIRT1 inhibitory compounds from the roots of Codonopsis pilosula. Journal of Asian Natural Products Research 2018, https://doi.org/10.1080/10286020.2017.1422491

20.??????????? Lu Dong, Li-Zhi Cheng, Yong-Ming Yan, Shu-Mei Wang, Yong-Xian Cheng*. Commiphoranes A-D, Carbon Skeletal Terpenoids from Resina commiphora. Organic Letters 2017, 19, 286–289.

21.??????????? Qi Luo, Zhu-Liang Yang, Yong-Ming Yan, Yong-Xian Cheng*. Ganotheaecolin A, a Neurotrophic Conjugated Ergosterol with a Naphtho[1,8-ef]azulene Scaffold from Ganoderma theaecolum. Organic Letters 2017, 19, 718–721.

22.??????????? Qi Luo, Zhen Wang, Jin-Feng Luo, Zheng-Chao Tu, Yong-Xian Cheng*. (±)-Applanatumines B–D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3. RSC Advances, 2017, 7, 38037–38043.

23.??????????? Tao Zheng, Yong-Ming Yan, Zheng-Chao Tu, Qi Luo, Fu-Rong Xu*, Yong-Xian Cheng*. Phenolic derivatives from Blaps japanensis and their biological evaluation. Fitoterapia 2017, 120, 58–60.

24.??????????? Ya-Mei Li, Bing Xiang, Xiao-Zheng Li, Yong-Ming Yan*, Yong-Xian Cheng*. New Diterpenoids from Clerodendranthus spicatus. Natural Products and Bioprospecting 2017, 7, 263–267.

25.??????????? Lu Dong, Qi Luo, Li-Zhi Cheng, Yong-Ming Yan, Yong-Xian Cheng*. Shu-Mei Wang*. New terpenoids from Resina Commiphora. Fitoterapia 2017, 117, 147–153.

26.??????????? Yong Luo, Li-Zhi Cheng, Qi Luo, Yong-Ming Yan, Shu-Mei Wang, Qin Sun*, Yong-Xian Cheng*. New ursane-type triterpenoids from Clerodendranthus spicatus. Fitoterapia 2017, 119, 69–74.

27.??????????? Xin Cheng, Yong-Qiang Liu, Gui-Zhen Wang, Li-Na Yang, Yong-Zhi Lu, Xin-Chun Li, Bo Zhou, Li-Wei Qu, Xiao-Lu Wang, Yong-Xian Cheng, Jin-Song Liu, Sheng-Ce Tao, Guang-Biao Zhou*. Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor. Oncotarget 2017, 8, 2681–2693.

28.??????????? Xin-Long Wang, Man Dou, Qi Luo, Li-Zhi Cheng, Yong-Ming Yan, Rong-Tao Li, Yong-Xian Cheng*. Racemic alkaloids from the fungus Ganoderma cochlear. Fitoterapia 2017, 116, 93–98.

29.??????????? Qi Luo, Xiao-Yi Wei, Jing Yang, Jin-Feng Luo, Rui Liang, Zheng-Chao Tu, Yong-Xian Cheng*. Spiro Meroterpenoids from Ganoderma applanatum. Journal of Natural Products 2017, 80, 61–70.

30.??????????? Qi Luo, Zheng-Chao Tu, Yong-Xian Cheng*.Two rare meroterpenoidal rotamers from Ganoderma applanatum. RSC Advances 2017, 7, 3413–3418.

31.??????????? Yong-Ming Yan, Hong-Jie Zhu, Bin Xiang, Jing-Jing Qi, Yong-Xian Cheng*. Phenolic Derivatives from Periplaneta americana. Natural Products Communications 2017, 12, 1769–1772.

32.??????????? Qi Luo, Yan-Jiao Zhang, Zhi-Qiang Shen, Peng Chen, Yong-Xian Cheng*. Shushe acids A-D from Ganoderma applanatum. Natural Products Communications 2017, xx, xx–xx..（电子版本中无卷，页码）

33.??????????? Qi Luo, Lei Di, Xiao-Hua Yang, Yong-Xian Cheng*. Applanatumols A and B, meroterpenoids with unprecedented skeletons from Ganoderma applanatum. RSC Advances 2016, 6, 45963–45967.

34.??????????? Xin-Long Wang, Feng-Jiao Zhou, Man Dou, Yong-Ming Yan, Shu-Mei Wang, Lei Di, Yong-Xian Cheng*. Cochlearoids F-K: Phenolic meroterpenoids from the fungus Ganoderma cochlear and their renoprotective activity. Bioorganic & Medicinal Chemistry Letters 2016, 26, 5507–5512.

35.??????????? Hong-Jie Zhu, Yong-Ming Yan, Zheng-Chao Tu, Jin-Feng Luo, Rui Liang, Tong-Hua Yang, Cheng, Yong-Xian*, Shu-Mei Wang*. Compounds from Polyphaga plancyi and their inhibitory activities against JAK3 and DDR1 kinases. Fitoterapia 2016, 114, 163–167.

36.??????????? Dong Chen, Wen-Dan Xu, Hao-Miao Liu, Ming-Ming Li, Yong-Min Yan, Xiao-Nian Li, Yan Li, Yong-Xian Cheng, Hong-Bo Qin*. Enantioselective total synthesis of (+)-Lingzhiol via tandem semipinacol rearrangement/Friedel-Crafts type cyclization. Chemical Communications 2016, 52(55), 8561–8564.

37.??????????? Wei-Yi Ding, Jun Ai, Xin-Long Wang, Fa-Yang Qiu, Qing Lv, Ping Fang, Fan-Fan Hou*, Yong-Ming Yan*, Yong-Xian Cheng*. Isolation of lingzhifuran A and lingzhilactones D-F from Ganoderma lucidum as specific Smad3 phosphorylation inhibitors and total synthesis of lingzhifuran A. RSC Advances 2016, 6(81), 77887–77897.

38.??????????? Wen-Wen Cao, Qi Luo, Yong-Xian Cheng*, Shu-Mei Wang*. Meroterpenoid enantiomers from Ganoderma sinensis. Fitoterapia 2016, 110, 110–115.

39.??????????? Man Dou, Rong-tao Li, Yong-Xian Cheng*. Minor compounds from fungus Ganoderma cochlear. Chinese Herbal Medicines 2016, 8(1), 85–88.

40.??????????? Qi Luo, Xiao-Hua Yang, Zhu-Liang Yang, Zheng-Chao Tu*, Yong-Xian Cheng*. Miscellaneous meroterpenoids from Ganoderma applanatum. Tetrahedron 2016, 72(30), 4564–4574.

41.??????????? Cheng-Gang Li, Qi Luo, Ping-Xia Guo, Li-Li Chen, Yong-Xian Cheng*. Petchiethers A and B, novel meroterpenoids with a 14- or 15-membered ring from Ganoderma petchii. Phytochemistry Letters 2016, 18, 14–18.

42.??????????? Dong Chen, Xiao-Mei Li, Hao-Miao Liu, Ming-Ming Li, Yong-Xian Cheng; Hong-Bo Qin*. Total synthesis of (±)-Lingzhilactone B via semipinacol rearrangement. Tetrahedron Letters 2016, 57(26), 2877–2879.

43.??????????? Jun Ai, Jing Nie, Jiang-Bo He, Qin Guo, Mei Li, Ying Lei, You-hua Liu, Zhan-Mei Zhou, Feng-Xin Zhu, Min Liang, Yong-Xian Cheng*, Fan-Fan Hou*. GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-induced Smad3 Phosphorylation. Journal of the American Society of Nephrology 2015, 26, 1827–1838.

44.??????????? Yong-Qiang Liu, Xiao-Lu Wang, Xin Cheng, Yong-Zhi Lu, Gui-Zhen Wang, Xin-Chun Li, Jian Zhang, Zhe-Sheng Wen, Zhi-Liang Huang, Qin-Lei Gao, Li-Na Yang, Yong-Xian Cheng*, Sheng-Ce Tao, Jin song Liu*, Guang-Biao Zhou*. Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget 2015, 6, 34953–34967.

45.??????????? Feng-Jiao Zhou, Yin Nian, Yong-Ming Yan, Ye Gong, Qi Luo, Yu Zhang, Bo Hou, Zhi-Li Zuo, Shu-Mei Wang, He-Hai Jiang, Jian Yang*, Yong-Xian Cheng*. Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear. Organic Letters 2015, 17, 3082–3085.

46.??????????? Qi Luo, Lei Tian, Lei Di,Yong-Ming Yan, Xiao-Yi Wei, Xin-Fang Wang, and Yong-Xian Cheng*. (±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Potent Smad3 Phosphorylation Inhibition from Ganoderma sinensis. Organic Letters 2015, 17, 1565–1568.

47.??????????? Qi Luo, Lei Di, Wei-Feng Dai, Qing Lu, Yong-Ming Yan, Zhu-Liang Yang, Rong-Tao Li, and Yong-Xian Cheng*.Applanatumin A, a New Dimeric Meroterpenoid from Ganoderma applanatum that Displays Potent Antifibrotic Activity. Organic Letters 2015, 17, 1110?1113.

48.??????????? Yong-Ming Yan, Xin-Long Wang, Li-Li Zhou, Feng-Jiao Zhou, Rong Li, Yuan Tian, Zhi-Li Zuo, Ping Fang, Arthur C. K. Chung, Fan-Fan Hou, Yong-Xian Cheng*. Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathyinmice Journal of Ethnopharmacology 2015, 176, 385–393.

49.??????????? Lei Di, Yan-Ni Shi, Yong-Ming Yan, Li-Ping Jiang, Bo Hou, Xin-Long Wang, Zhi-Li Zuo,* Yong-Bin Chen, Cui-Ping Yang* and Yong-Xian Cheng*. Nonpeptide small molecules from the insect Aspongopus chinensis and their neural stem cell proliferation stimulating properties. RSC Advances 2015, 5, 70985–70991.

50.??????????? Yong-Ming Yan, Li-Ji Li, Xiao-Chu Qin, Zheng-Chao Tu, Qing Lu, Yong-Xian Cheng*. Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities. Bioorganic & Medicinal Chemistry Letters 2015, 25, 2469–2472.

51.??????????? Yong-Ming Yan, Xin-Long Wang, Qi Luo, Li-Ping Jiang, Cui-Ping Yang, Bo Hou, Zhi-Li Zuo, Yong-Bin Chen, Yong-Xian Cheng*. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry 2015, 114, 155–162.

52.??????????? Jiang-Bo He, Qing Lu, Yong-Xian Cheng*. Two new sesquiterpenes from the resin of Toxicodendron vernicifluum. Helvetica Chimica Acta 2015, 98, 1004–1008.

53.??????????? Wei-Feng Dai, Ping-Xia Guo, Zheng-Chao Tu, Rong-Tao Li, Yong-Xian Cheng*. Five new compounds from the fungus Ganoderma petchii. Fitoterapia 2015, 106, 68–71.

54.??????????? Qin-Lei Gao, Ping-Xia Guo, Qi Luo, Hui Yan and Yong-Xian Cheng*. Petchienes A–E, Meroterpenoids from Ganoderma petchii. Natural Product Communications 2015, 10, 2019–2022.

55.??????????? Yong-Xun Yang, Qi Luo, Bo Hou, Yong-Ming Yan, Yue-Hu Wang, Jian-Jun Tang, Xiao-Ping Dong, Xiu-Ying Ma, Tong-Hua Yang, Zhi-Li Zuo, Yong-Xian Cheng*. Periplanosides A–C: new insect-derived dihydroisocoumarin glucosides from Periplaneta americana stimulating collagen production in human dermal fibroblasts. Journal of Asian Natural Products Research 2015, 17, 988–995.

56.??????????? Yong-Ming Yan,Ping Fang, Mu-Tian Yang, Ning Li, Qing Lu, Yong-Xian Cheng*. Anti-diabetic nephropathy compounds from Cinnamomum cassia. Journal of Ethnopharmacology 2015, 165, 141–147.

57.??????????? Qi Luo, Xin-Long Wang, Lei Di, Yong-Ming Yan, Qing Lu, Xiao-Hua Yang, Dong-Bao Hu, and Yong-Xian Cheng*. Isolation and identification of renoprotective substances from the mushroom Ganoderma lucidum. Tetrahedron 2015, 71, 840–845.

58.??????????? Jian-Jun Tang, Ping Fang, Hou-Lin Xia, Zheng-Chao Tu, Bi-Yu Hou, Yong-Ming Yan, Lei Di, Li Zhang*, Yong-Xian Cheng*. Constituents from the edible Chinese black ants (Polyrhachis dives) showing protective effect on rat mesangial cells and anti-inflammatory activity. Food Research International 2015, 67, 163–168.

59.??????????? Jian-Jun Tang, Qi Luo, Lei Di, Li Zhang, Qing Lu, Bo Hou, Zhi-Li Zuo, Hou-Lin Xia*, Xiu-Jing Ma*, Yong-Xian Cheng*. Compounds from the Chinese black ant (Polyrhachis dives) and NMR behavior of the isomers with formamide group. Journal of Asian Natural Products Research 2015, 17, 20–26.

60.??????????? Juan Lu, Qin Sun, Zheng-Chao Tu, Qing Lv, Pi-Xian Shui,* and Yong-Xian Cheng*. Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities. Molecules 2015, 20, 15589?15596.

61.??????????? Dong Chen, Hao-Miao Liu, Ming-Ming Li, Yong-Min Yan, Wen-Dan Xu, Xiao-Nian Li, Yong-Xian Cheng, and Hong-Bo Qin*, A Concise Synthesis of (±)-Lingzhiol via Epoxy-arene Cyclization. Chemical Communications 2015, 51, 14594–14596.

62.??????????? Man Dou, Lei Di, Li-Li Zhou, Yong-Ming Yan, Xin-Long Wang, Feng-Jiao Zhou, Zhu-Liang Yang,Rong-Tao Li*, Fan-Fan Hou*, Yong-Xian Cheng*. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.Organic Letters 2014, 16, 6064–6067.

63.??????????? Yong-Ming Yan, Jun Ai, Yan-Ni Shi, Zhi-Li Zuo, Bo Hou, Jie Luo, Yong-Xian Cheng*. (±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3. Organic Letters 2014, 16, 532?535.

64.??????????? Xin-Fang Wang, Yong-Ming Yan, Xin-Long Wang, Xiu-Jing Ma*, Xue-Yan Fu*, Yong-Xian Cheng*. Two new compounds from Ganoderma lucidum.Journal of Asian Natural Products Research 2014, 17, 329–332.

65.??????????? Yan-Ni Shi, Zheng-Chao Tu, Xin-Long Wang, Yong-Ming Yan, Ping Fang, Zhi-Li Zuo, Bo Hou, Tong-Hua Yang*, Yong-Xian Cheng*. Bioactive compounds from the insect Aspongopus chinensis. Bioorganic & Medicinal Chemistry Letters 2014, 24, 5164–5169.

66.??????????? Jian-Jun Tang, Li Zhang, Li-Ping Jiang, Lei Di, Yong-Ming Yan, Zheng-Chao Tu*, Cui-Ping Yang, Zhi-Li Zuo, Bo Hou, Hou-Lin Xia, Yong-Bin Chen*, Yong-Xian Cheng*. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation. Tetrahedron 2014, 70, 8852–8857.

67.??????????? Xin-Long Wang, Min Hu, Shuang Wang, Yong-Xian Cheng*. Phenolic Compounds and Steroids from Rumex patientia. Chemistry of Natural Compounds 2014, 50, 311–313.

68.??????????? Wei Ma, Kai-Jin Wang, Chen-Shu Cheng, Guo-Qing Yan, Wei-Li Lu, Jing-Fang Ge, Yong-Xian Cheng*, Ning Li*. Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy. Journal of Ethnopharmacology 2014, 153, 840–845.

69.??????????? Bo Hou, Ping-Gui Yi, Zhao-Xu Wang, Shu-Qun Zhang, Jin-Hua Zhao, Ricardo L. Mancera, Yong-Xian Cheng*, Zhi-Li Zuo*. Assignment of aromaticity of the classic hetero benzenes by three aromatic criteria. Computational and Theoretical Chemistry 2014, 1046, 20?24.

70.??????????? Li-Jing Fang, Chun-Lei Wu, Zai-Dan Yu, Peng Shang, Yong-Xian Cheng, Yue-Feng Peng, Wu Su. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A. European Journal of Organic Chemistry 2014, 34, 7572?7576.

71.??????????? Xiao-Xiao Wang, Yong-Xian Cheng, Xiao-Shuang Chen, Jin-Hua Liao, Juan Yang, Xu-Jia Hu, Comparison of Natural and Synthetic alpha-Tocopherol in Rat Plasma by HPLC and Euryale ferox Seed as a Source of Natural alpha-Tocopherol. Asian Journal of Chemistry 2014, 26, 5279?5282.

72.??????????? Yong-Ming Yan, Jun Ai, Li-Li Zhou, Arthur C.K. Chung, Rong Li, Jing Nie, Ping Fang, Xin-Long Wang, Jie Luo, Qun Hu, Fan-Fan Hou*,Yong-Xian Cheng*. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum. Organic Letters 2013, 15, 5488–5491.

73.??????????? Jiang-Bo He, Jie Luo, Li Zhang, Yong-Ming Yan, Yong-Xian Cheng*. Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors. Organic Letters 2013, 15, 3602–3605.

74.??????????? Qi Luo, Shu-Mei Wang, Qing Lu, Jie Luo, Yong-Xian Cheng*. Identification of Compounds from the Water Soluble Extract of Cinnamomum cassia Barks and Their Inhibitory Effects against High-Glucose-Induced Mesangial Cell. Molecules 2013, 18, 10930–10943.

75.??????????? Mei Yang, Jiang-Bo He, Yong-Xian Cheng*, Sheng Jiang*. Synthesis of 3-[(Z)-Pentadec-8-Enyl] Catechol and Its Anti-angiogenesis Activity. Chinese Journal of Organic Chemistry 2013, 33, 1319–1325.

76.??????????? Yang Yang, Yong-Ming Yan, Wei Wei, Jie Luo, Lan-Sheng Zhang, Xiao-Jiang Zhou, Peng-Cheng Wang, Yong-Xun Yang, Yong-Xian Cheng*. Anthraquinone Derivatives from Rumex Plants and Endophytic Aspergillus fumigatus and Their Effects on Diabetic Nephropathy. Bioorganic & Medicinal Chemistry Letters 2013, 23, 3905–3909.

77.??????????? Ying Liu, Ying Dong, Bo Zhang, Yong-Xian Cheng*. Small compound 6-O-angeloylplenolin induces caspase-dependent apoptosis in human multiple myeloma cells. Oncology Letters 2013, 6, 556–558.

78.??????????? Wen-Gui Li, Fei-Yan Dai, Yong-Xian Cheng*, Ge-Fen Yin, Jun-Long Bi, Dian-Peng Li. Identification of Porcine Reproductive and Respiratory Syndrome Virus Inhibitors through an Oriented Screening on Natural Products. Chemical Research in Chinese Universities 2013, 29, 290–293.

79.??????????? Yong-Ming Yan, Min Hu, Mei Yang, Xiao-Ping Dong and Yong-Xian Cheng*. Terpenoids from Incarvillea arguta. Journal of Asian Natural Products Research 2013, 15, 9–14.

80.??????????? Zhi-Fang Zhao, Li-Li Zhou, Xia Chen, Yong-Xian Cheng, Fan-Fan Hou, Jing Nie*, Acortatarin A Inhibits High Glucose-Induced Extracellular Matrix Production in Mesangial Cells. Chinese Medical Journal 2013, 126, 1230–1235.

81.??????????? Lin-Hong Zeng, Min Hu, Yong-Ming Yan, Qing Lu and Yong-Xian Cheng*. Compounds from the roots of Jasminum sambac. Journal of Asian Natural Products Research 2012, 14, 1180–1185.

82.??????????? Xiao-Jiang Zhou, Xue-Song Li, Ying Shen, Gang Pei, Jun-Feng Wang, Yong-Xian Cheng*. Steroids and Triterpenoids from Cucumis sativus Roots. Chemistry of Natural Compounds 2012, 48, 419–422.

83.??????????? Yong-Ming Yan, Huan-Qin Dai, Yu-Hong Du, Bernd Schneider, Hui Guo, Dian-Peng Li, Li-Xin Zhang*, Hai-An Fu*, Yong-Xian Cheng*. Identification of Blapsins A and B as Potent Small-Molecule 14-3-3 Inhibitors from the Insect Blaps japanensis. Bioorganic & Medicinal Chemistry Letters 2012, 22, 4179–4181.

84.??????????? Yong-Ming Yan, Gui-Sheng Wu, Xiao-Ping Dong, Lan Shen, Yan Li, Jia Su, Huai-Rong Luo, Hua-Jie Zhu*, and Yong-Xian Cheng*. Sesquiterpenoids from Incarvillea arguta: Absolute Configuration and Biological Evaluation. Journal of Natural Products 2012, 75, 1025–1029.

85.??????????? Xi Li, Wei Cao, Ying Shen, Dian-Peng Li, Ning Li, Xiao-Ping Dong, Kai-Jin Wang, and Yong-Xian Cheng*. Antioxidant Compounds from Rosa laevigata Fruits. Food Chemistry 2012, 130, 575–580.

86.??????????? Y-J Li, X. Zhao, L.M. Vecchiarelli-Federico, Y. Li, A. Datti, Y.X. Cheng and Y Ben-David*, Drug-mediated Inhibition of Fli-1 for the Treatment of Leukemia. Blood Cancer Journal. 2012(2), e54 DOI:10.1038/bcj.2011.52.

87.??????????? Chang-Wei Song, Shu-Mei Wang, Li-Li Zhou, Fan-Fan Hou, Kai-Jin Wang, Quan-Bin Han, Ning Li, Yong-Xian Cheng*. Isolation and Identification of Compounds Responsible for Antioxidant Capacity of Euryale ferox Seeds. Journal of Agricultural and Food Chemistry 2011, 59, 1199–1204.

88.??????? Jun Zhao,Li-Li Zhou,Xi Li, Hong-Bin Xiao, Fan-Fan Hou*,and Yong-Xian Cheng*. Bioactive Compounds from the Aerial Parts of Brachystemma calycinum and Structural Revision of an Octacyclopeptide. Journal of Natural Products 2011, 74, 1392?1400.

89.??????????? Yong-Xian Cheng*,Li-Li Zhou, Yong-Ming Yan, Ke-Xin Chen, Fan-Fan Hou*. Diabetic Nephropathy-Related Active Cyclic Peptides from the Roots of Brachystemma calycinum.Bioorganic & Medicinal Chemistry Letters 2011, 21, 7434?7439.

90.??????????? Xiao-Jiang Zhou, Xiao-Liang Chen, Xue-Song Li, Jia Su, Jiang-Bo He, Yue-Hu Wang, Yan Li,Yong-Xian Cheng*. Two Dimeric Lignans with an Unusual Alpha, Beta-Unsaturated Ketone Motif from Zanthoxylum podocarpum and their Inhibitory Effects on Nitric Oxide Production. Bioorganic & Medicinal Chemistry Letters 2011, 21, 373–376.

91.??????????? Jun-Feng Wang, Ge-Fen Yin, Xiao-Jiang Zhou, Jia Su, Yan Li, Hui-Min Zhong, Gang Duan*, and Yong-Xian Cheng*. Flavonolignans from Hydnocarpus anthelminthica Seeds Inhibit Nitric Oxide Production in LPS Stimulated RAW 264.7 Macrophage Cell Line. Journal of Asian Natural Products Research 2011, 13, 80–83.

92.??????????? Xiao-Jiang Zhou, Min Xu, Xue-Song Li, Yue-Hu Wang, Ye Gao, Rui Cai, Yong-Xian Cheng*. Triterpenoids and Sterones from the Stem Bark of Ailanthus altissima. Bulletin of Korean Chemical Society 2011, 32, 1–4.

93.??????????? Ying Liu,Xiao-Qin Chen,Heng-Xing Liang, Feng-Xiang Zhang,Fan-Yi Meng,Yong-Xian Cheng*, and Guang-Biao Zhou*. Small Compound 6-O-Angeloylplenolin Induces Mitotic Arrest and Exhibits Therapeutic Potential in Multiple Myeloma. PLoS One 2011, 6(7), 134–134

94.??????????? Ren-Qiang Mei, Lin-Hong Zeng, Xiang-Tao Wang, Rui Chen, Huai-Rong Luo and Yong-Xian Cheng*. N-Containing Compounds from Broussonetia papyrifera Seeds and Their cAMP Regulatory Activity in N1E-115 Cells. Chemistry of Natural Compounds 2011, 47, 783–785.

95.??????? Xiao-Jiang Zhou, Zhou Xie, Yong-Ming Yan,Xue-Song Li, Bing Wang, Yong-Xian Cheng*. A New Lignan from the Leaves of Loropetalum chinensis. Chemistry of Natural Compounds 2011, 47, 690?692.

96.??????????? Jiang-Bo He, Yong-Ming Yan, Gui-Fen Luo, Xue-Song Li, Jia Su, Yan Li, Guang-Ming Liu, and Yong-Xian Cheng*. Sesquiterpenoids and Diarylheptanoids from an Animal Product Nidus Vespae and Their Inhibitory Effects on Nitric Oxide Production. Chemistry & Biodiversity 2011, 8, 2270?2276.

97.??????????? Xue-Song Li,Xiao-Jiang Zhou,Xing-Jie Zhang, Xue-Jing Li, Mei Yang,Yong-Ming Yan, Yong-Tang Zheng, Yan Li, Liu-Meng Yang, and Yong-Xian Cheng*. Sesquiterpenoidal and Norsesquiterpenoidal Derivatives from Sanicula lamelligera and Their Biological Evaluation. Journal of Natural Products 2011, 74, 1521?1525.

98.??????????? Jun Zhao, Lin-Hong Zeng, Xi Li, Xiao-Ping Dong, Yong-Ming Yan,Yong-Xian Cheng*. Brachystemols A–C, Three New Furan Derivatives from Brachystemma calycinum. Journal of Asian Natural Products Research 2011, 13, 915?919.

99.??????????? Xiao-Gang Tong, Li-Li Zhou, Yue-Hu Wang, Cheng Feng Xia, Ye Wang, Min Liang, Fan-Fan Hou*, and Yong-Xian Cheng*. Acortatarins A and B, Two Novel Antioxidative Spiroalkaloids with a Naturally Unusual Morpholine Motif from Acorus tatarinowii. Organic Letters 2010, 12, 1844–1847.

100.??????????? Xiao-Gang Tong, Gui-Sheng Wu, Cheng-Gang Huang, Qing Lu, Yue-Hu Wang, Chun-Lin Long, Huai-Rong Luo, Hua-Jie Zhu*, and Yong-Xian Cheng*. Compounds from Acorus tatarinowii: Determination of the Absolute Configurations by Quantum Computations and cAMP Regulation Activity. Journal of Natural Products 2010, 73, 1160–1163.

101.??????????? Jun Zhao, Hua-Jie Zhu, Xiao-Jiang Zhou, Tong-Hua Yang, Yuan-Yuan Wang, Jia Su, Yan Li*, and Yong-Xian Cheng*. Diterpenoids from Trogopterus xanthipes. Journal of Natural Products 2010, 73, 865–869.

102.??????????? Xiao-Gang Tong, Jin-Lei Liu and Yong-Xian Cheng*. A New Pregnane Steroid from Poria cum Radix Pini. Journal of Asian Natural Products Research 2010, 12, 419–423.

103.??????????? Xiao-Jiang Zhou, Ren-Qiang Mei, Li Zhang, Qing Lu, Jun Zhao, Abiodun Humphrey Adebayo, Yong-Xian Cheng*. Antioxidant Phenolics from Broussonetia papyrifera fruits.Journal of Asian Natural Products Research 2010, 12, 399–406.

104.??????????? Heng-Xing Liang, Huan-Qin Dai, Hai-An Fu, Xiao-Ping Dong, Abiodun Humphrey Adebayo, Li-Xin Zhang*, Yong-Xian Cheng*. Bioactive Compounds from the Roots of Rumex nepalensis. Phytochemistry Letters 2010, 3, 181–184.

105.??????????? Jiang-Bo He, Hua-Jie Zhu, Gui-Fen Luo, Guang-Ming Liu, Hao Chen, Yan Li, Shao-Peng Chen, Xin Lu, Guo-Chun Zhou, Yong-Xian Cheng*. New Compounds from Euphorbia helioscopia and Absolute Configuration Determination by Computational Methods.Bulletin of Korean Chemical Society 2010, 31, 2211–2214.

106.??????????? Junfeng Wang, Huanqin Dai, Yuling Wei, Huajie Zhu, Yongming Yan, Yuehu Wang, Chunlin Long, Huimin Zhong, Lixin Zhang*, and Yongxian Cheng*. Anti-Tuberculosis Agents and an Inhibitor of Para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds. Chemistry & Biodiversity 2010, 7, 2046–2053.

107.??????????? Xiao-Gang Tong, Bin Qiu, Gui-Fen Luo, Xiao-Fang Zhang, Yong-Xian Cheng*. Alkaloids and Sesquiterpenoids from Acorus tatarinowii. Journal of Asian Natural Products Research 2010, 12, 438–442.

108.??????????? Li Zhang, Yong-Xian Cheng, Ai-Lin Liu, Hai-Di Wang, Ya-Ling Wang, Guan-Hua Du*, Anti-Oxidant, Anti-Inflammatory, Anti-Influenza Properties of Compounds from Chaenomeles speciosa. Molecules 2010, 15, 8507–8517.

109.??????????? Junfeng Wang, Huanqin Dai, Yuling Wei, Huajie Zhu, Yongming Yan, Yuehu Wang, Chunlin Long, Huimin Zhong, Lixin Zhang*, and Yongxian Cheng*. Anti-Tuberculosis Agents and an Inhibitor of Para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds. Chemistry & Biodiversity 2010, 7, 2046–2053.

110.??????????? Xiao-Gang Tong, Bin Qiu, Gui-Fen Luo, Xiao-Fang Zhang, Yong-Xian Cheng*. Alkaloids and Sesquiterpenoids from Acorus tatarinowii. Journal of Asian Natural Products Research 2010, 12, 438–442.

111.??????????? Li Zhang, Yong-Xian Cheng*, Ai-Lin Liu, Hai-Di Wang, Ya-Ling Wang, Guan-Hua Du*. Anti-Oxidant, Anti-Inflammatory, Anti-Influenza Properties of Compounds from Chaenomeles speciosa. Molecules 2010, 15, 8507–8517.

112.??????????? Ren-Qiang Mei, Yue-Hu Wang, Guan-Hua Du, Guang-Ming Liu, Li Zhang*, Yong-Xian Cheng*. Antioxidant Lignans from the Fruits of Broussonetia papyrifera. Journal of Natural Products 2009, 72, 621?625.

113.??????????? Ren-Qiang Mei, Hen-Xing Liang, Jun-Feng Wang, Lin-Hong Zeng, Qing Lu, Yong-Xian Cheng*. New Seco-Anthraquinone Glucosides from Rumex nepalensis. Planta Medica 2009, 75, 1162?1164.

114.??????????? Jun-Feng Wang, Cun-Li Zhang, Qing Lu, Ya-Fang Yu, Hui-Min Zhong, Chun-Lin Long, Yong-Xian Cheng*. Three New Diarylheptanoids from Myrica nana.Helvetica Chimica Acta 2009, 92, 1594?1599.

115.??????????? Lan-Sheng Zhang, Zhen Li, Ren-Qiang Mei, Guang-Ming Liu, Chun-Lin Long, Yue-Hu Wang, Yong-Xian Cheng*. Hastatusides A and B: Two New Phenolic GlucosideS from Rumex hastatus. Helvetica Chimica Acta 2009, 92, 774?778.

116.??????????? Jun-feng Wang，Sha-sha Dong, Yue-hu Wang, Qing-Lu, Hui-min Zhong, Guan-hua Du, Li Zhang*, Yong-xian Cheng*. Cyclic Diarylheptanoids from Myrica Nana Inhibiting Nitric Oxide Release. Bioorganic & Medicinal Chemistry 2008, 16, 8510?8515.

117.??????????? Ya-Ling Song, Li Zhang, Jin-Ming Gao, Guan-Hua Du and Yong-Xian Cheng*. Speciosaperoxide, a new triterpene acid and other terpenoids from Chaenomeles speciosa. Journal of Asian Natural Products Research 2008, 10, 214?217.

118.??????????? Ya-Ling Song, Yue-Hu Wang, Qing Lu, Hui-Jun Qiao, Yong-Xian Cheng*. Triterpenoids from the Edible Leaves of Photinia serrulata. Helvtica Chimica Acta 2008, 91, 665?672.

119.??????????? ?Ren-Qiang Mei, Qing Lu, Yan-Fen Hu, Hai-Yang Liu, Fu-Kai Bao, Yu Zhang, Yong-Xian Cheng*. Three New Polyyne (=Polyacetylene) Glucosides from the Edible Roots of Codonopsis cordifolioidea. Helvtica Chimica Acta 2008, 91, 90?96.

120.??????????? Yong-li Zhang, Fu-kai Bao, Juan-juan Hu, Sheng-wang Liang, Yu Zhang, Guan-hua Du, Cai-jun Zhang, Yong-xian Cheng*. Antibacterial Lignans and Triterpenoids from Rostellularia procumbens. Planta Medica 2007, 73, 1596?1599.

121.??????????? ?Heng-xing Liang, Fu-kai Bao, Xiao-ping Dong, Hua-jie Zhu, Xiao-jie Lu, Ming Shi, Qing Lu, Yong-xian Cheng*.Two New Antibacterial Sesquiterpenoids from Centipeda minima.Chemistry & Biodiversity 2007, 4, 2948?2952.

122.??????????? Heng-xing Liang, Fu-kai Bao, Xiao-ping Dong, Rui Tan, Cai-jun Zhang, Qing Lu,Yong-xian Cheng*.Antibacterial Thymol Derivatives Isolated from Centipeda minima.Molecules 2007, 12, 1606?1613.

123.??????????? Qing Lu, Li Zhang, Guo-rong He, Heng-xing Liang, Guan-hua Du,Yong-xian Cheng*. Two New Alkaloids from Brachystemma calycinum and Their Inhibitory Effects on T- and B-lymphocytes Proliferation.Chemistry & Biodiversity 2007, 4, 2810?2816.

124.??????????? Ya-ling Song, Yue-hu Wang, Qing Lu, Jin-ming Gao, Ming-gang Bi,Yong-xian Cheng*. Two New Triterpenoids from Photinia serrulata.Molecules 2007, 12, 2599?2604.

125.??????????? Ya-fang Yu, Qing Lu, Li Guo, Ren-qiang Mei, Heng-xing Liang, Du-qiang Luo,Yong-xian Cheng*. Myricananone and Myricananadiol: Two New Cyclic Diarylheptanoids from the Roots of Myrica nana. Helvetica Chimica Acta 2007, 90, 1691?1696.

126.??????????? Yong-xian Cheng, Bernd Schneider, Ulrike Riese, Matthias Hamburger*. (+)-Deoxymilitarinone A, a Pyrridone Alkaloid with Neurogenic Potential in PC 12 Cells from Insect-Pathogenic Fungus Paecilomyces farinosus. Journal of Natural Products 2006, 69,436?438.

127.??????????? Yong-xian Cheng, Bernd Schneider, Christine Oberthür, Heidemarie Graf, Sven Adler, and Matthias Hamburger*. Flavone C-Glycosides from Isatis tinctoria Leaves. Heterocycles 2005, 65, 1655?1661.

128.??????????? Yong-xian Cheng, Bernd Schneider, Ulrike Riese, Barbara Schubert, Zengzhi Li, Matthias Hamburger*. Farinosones A-C, New Neurotrophic Alkaloidal Metabolites from the Entomogenous Deuteromycete Paecilomyces farinosus. Journal of Natural Products 2004, 67, 1854?1858.

129.??????????? Cheng Wang, Li-Li Zhang, Yang Lu, Qi-Tai Zheng, Yong-Xian Cheng, Jun Zhou, Ning-Hua Tan. Study on the Spatial Structure of Brachystemin C, a New Cyclic Peptide from Brachystemma calycinum. Journal of Molecular Structure 2004, 688, 67?71.

130.??????????? Yongxian Cheng,Jun Zhou*, Shiming Deng and Ninghua Tan. New Norsesquiterpenoids from Cucubalus baccifer. Planta Medica 2002, 68, 91?94.

131.??????????? Yong-Xian Cheng, Jun Zhou*, Ninghua Tan, Rongwei Teng, Yang Lu Cheng Wang and Qitai Zheng. Isolation and Characterization of Brachystenidines A-E, Novel Alkaloids from Brachystemma calycinum.Journal of Natural Products 2002, 65, 750?752.

132.??????????? Yong-xian Cheng, Jun Zhou*, Ning-hua Tan, Qi-tai Zheng, Ning-bo Gong and Yang Lu. Crystal Structure of Cucubaldiol, a Novel Norsesquiterpenoid Incorporating a Bicyclo[2.2.2]octene Ring System from Cucubalus baccifer (Caryophyllaceae). Helvetica Chimica Acta 2001, 84, 2343?2346.

133.??????????? Yong-xian Cheng, Jun Zhou*, Tan Ninghua, Lu Yang, Liu Xuying, Zheng Qitai. Cucubalactam and brachystemin E, Two New Compounds from Caryophyllaceae. Heterocycles 2001, 55, 1943?1949.

134.??????????? Yong-Xian Cheng, Jun Zhou, Hao-Fu Dai, Zhong-Tao Ding. Cucubalugenin A, A New Triterpenoid from Cucubalus baccifer. Fitoterapia 2001, 72, 848?849.

135.??????????? Yong-Xian Cheng, Jun Zhou, Ning-Hua Tan, Zhong-Tao Ding. A New Cyclopeptide from Brachystemma calycinum. Chinese Chemical Letters 2000, 11, 595?596.

136.??????????? Zhong-Tao Ding, Jun Zhou, Yong-Xian Cheng, Ning-Hua Tan. A New Cyclopeptide from Polycarpon prostratum. Chinese Chemical Letters 2000, 11, 593?594.

137.??????????? Shi-Ming Deng, Jun Zhou, Yong-Xian Cheng, Hao-Fu Dai, Ning-Hua Tan. Two New Phenolic Glycosides from Magnolia rostrata.Chinese Chemical Letters 2000, 11, 1001?1002.

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